Microstructural Changes in Higher-Order Nuclei of the Thalamus in Patients With First-Episode Psychosis

摘要

BACKGROUND: Disruption in the thalamus, such as volume, shape, and cortical connectivity, is regarded as an important pathophysiological mechanism in schizophrenia. However, there is little evidence of nuclei-specific structural alterations in the thalamus during early-stage psychosis, mainly because of the methodological limitations of conventional structural imaging in identifying the thalamic nuclei.