pde4 inhibition, compound, pharmaceutical composition, method for inhibiting pde4 enzyme, enhancing cognition and / or treating psychosis in a patient, method for treating a patient having a disease involving decreased camp levels, method for the treatment of a patient suffering from an allergic or inflammatory disease and method for the treatment of a patient suffering from neurodegeneration resulting from an illness or injury

摘要

"PDE4 INHIBITION, COMPOUND, PHARMACEUTICAL COMPOSITION, METHOD FOR INHIBITING THE PDE4 ENZYME, INCREMENTING COGNITION AND / OR TREATING PSYCHOSIS IN A PATIENT, METHOD FOR TREATMENT OF A PAIN IN A PAVEMENT THAT HAS A PAVEMENT THAT HAS METHOD FOR THE TREATMENT OF A PATIENT SUFFERING FROM AN ALLERGIC OR INFLAMMATORY DISEASE AND METHOD FOR THE TREATMENT OF A PATIENT SUFFERING FROM NEURODEGENERATION RESULTING FROM A DISEASE OR INJURY ". Selective PDE4 inhibition is obtained by 4- (substituted phenyl) -2-pyrrolidinone compounds. The compounds exhibit improved PDE4 inhibition compared to compounds such as rolipram and show selectivity with respect to inhibition of other classes of PDEs. The compounds of the present invention are of formula I: wherein R¬1¬, R¬2¬ and R¬3¬ are as defined herein.