Relationship of IL-17A and IL-17F genetic variations to cervical cancer risk: a meta-analysis

摘要

Aim: We performed a meta-analysis to determine a more precise relationship of IL-17A and IL-17F polymorphisms with cervical cancer risk. Materials & methods: PubMed, CNKI and Wan Fang databases were searched for studies on these associations using STATA version 10.0 software. Results: Five studies were included. The AG and AA genotypes and A allele of IL-17A rs2275913 were correlated with an elevated risk of cervical cancer. The TT genotype and T allele of IL-17A rs3748067 and the CC genotype and C allele of IL-17F rs763780 carried a moderate risk of cervical cancer, when compared with the wild-type genotype. Conclusion: IL-17A and IL-17F polymorphisms therefore have the potential to act as predictive biomarkers for cervical cancer risk.