IL-17F基因多态性与类风湿关节炎发病风险关系的Meta分析

摘要

目的:探讨白介素17F(IL-17F)基因多态性rs763780和rs2397084与类风湿关节炎(RA)易感性的关系.方法:计算机检索中国学术期刊全文数据库、万方数据库、中国生物医学文献数据库、Pubmed、Embase以及Web of Science中已发表的与RA和IL-17F基因多态性相关文献,进行Meta分析.结果:纳入的5项研究共收集RA患者1 174例(其中rs763780含1 174例,rs2397084含985例),正常对照966例(rs763780含966例,rs2397084含766例).Meta分析结果显示,rs763780与RA密切相关(C vs.T:OR=1.74,95%CI=1.01-2.98,P=0.04;CC vs.TT:OR=3.17,95%CI=1.21-8.35,P=0.02;CT vs.TT:OR=1.80,95%CI=1.21-2.66,P=0.004;CC+CT vs.TT:OR=1.96,95%CI=1.35-2.83,P<0.001;CC vs.CT+ TT:OR=2.97,95%CI=1.13-2.66,P=0.03).根据人种进行亚组分析发现,在欧洲人群中rs763780与RA密切相关,差异具有统计学意义.未发现rs2397084与RA之间的相关性.结论:IL-17F rs763780 是RA的危险因素,IL-17F rs2397084与RA易感性是否有关仍不明确.%Objective:To explore the association between rheumatoid arthritis(RA)and two polymorphisms of interleukin-17(IL-17F)rs763780 and rs2397084.Methods: A systematic search of relevant studies was conducted in China National Knowledge Infrastructure,Wanfang Chinese Periodical Database,China Biology Medical Literature Database,Pubmed,Embase and Web of Science.Results: A total of 5 case-control studies including 1 174 RA cases and 966 health controls for rs763780 and 985 RA cases and 766 health controls for rs2397084 were included in this Meta-analysis.The results showed that rs763780 was significantly associated with increased susceptibility to RA(C vs.T:OR=1.74,95%CI=1.01-2.98,P=0.04;CC vs.TT:OR=3.17,95%CI=1.21-8.35,P=0.02;CT vs.TT:OR=1.80,95%CI=1.21-2.66,P=0.004;CC+CT vs.TT:OR=1.96,95%CI=1.35-2.83,P<0.001;CC vs.CT+ TT:OR=2.97,95%CI=1.13-2.66,P=0.03).In subgroup analysis based on ethnicity,rs763780 was positively correlated with RA in Europeans.No significant association was found between rs2397084 and RA.Conclusion: The present study revealed that IL-17F rs763780 polymorphism is a risk factor of RA,while the association of rs2397084 with RA remains uncertain.