首页> 外文期刊>Cytogenetic and genome research >Chromosomal Polymorphisms in African Vlei Rats, Otomys irroratus (Muridae: Otomyini), Detected by Banding Techniques and Chromosome Painting: Inversions, Centromeric Shifts and Diploid Number Variation
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Chromosomal Polymorphisms in African Vlei Rats, Otomys irroratus (Muridae: Otomyini), Detected by Banding Techniques and Chromosome Painting: Inversions, Centromeric Shifts and Diploid Number Variation

机译:在非洲Vlei大鼠,Otomys irroratus(Muridae:Otomyini)的染色体多态性,通过绑定技术和染色体绘画检测:反转,着丝粒转变和二倍体数变异。

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Pericentric inversions are important for evolutionary biology because of their potential role in speciation. They may result in reproductive isolation due to illegitimate pairing of homologues at meiosis which leads to the production of aneuploid gametes (containing deletions or duplications of chromosomal segments), and consequently mediate chromosomal divergence. In this study, we describe the prevalence of pericentric inversions in the African vlei rat, Otomys irroratus (OIR). The species is characterized by intraspecific chromosomal variation (2n = 23-32) across its distribution in southern Africa. Here, we analyzed 55 individuals collected from 7 localities in South Africa by G-and C-banding and chromosome painting with flow sorts of Myotomys unisulcatus. Of the 55 specimens that were analyzed, 47% contained inversions or centromeric shifts on 4 autosomes (OIR1, 4, 6 and 10) which were present singly in specimens (i.e. none of the specimens contained all 4 inversions concurrently). These inversions were found in both homozygous and heterozygous state over a wide geographic range suggesting that they are floating polymorphisms. Given the potential role of inversions in post-mating isolation (through production of aneuploid gametes), the prevalence of inversions as floating polymorphisms in the vlei rats suggests that they are probably retained in the population through suppression of recombination in the inverted regions of the chromosomes.
机译:周缘反转对进化生物学很重要,因为它们在物种形成中具有潜在作用。由于减数分裂时同源物的配对不正确,它们可能导致生殖隔离,从而导致产生非整倍体配子(包含染色体节段的缺失或重复),从而介导染色体发散。在这项研究中,我们描述了非洲vlei大鼠,Otomys irroratus(OIR)周围性内向倒置的患病率。该物种的特征是在整个南部非洲分布的种内染色体变异(2n = 23-32)。在这里,我们分析了来自南非7个地区的55个个体,这些个体通过流线型Myotomys unisulcatus进行G带和C带采集以及染色体涂画。在分析的55个样本中,有47%的样本包含4个常染色体(OIR1、4、6和10)的倒位或着丝粒移位(即没有一个样本同时包含全部4个倒位)。在广泛的地理范围内以纯合和杂合状态都发现了这些倒位,表明它们是浮动多态性。鉴于倒置在交配后分离中的潜在作用(通过产生非整倍体配子),在vlei大鼠中倒置的普遍性为浮动多态性,表明它们可能通过抑制染色体倒置区域的重组而保留在种群中。 。

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