Hantzsch 1,4-dihydropyridine esters and analogs:candidates for generating reproducible one-dimen-sional packing motifs

摘要

Examination of the symmetric Hantzsch 1,4-dihydropyridineester derivatives of the prototypical nifedipine moleculeindicates the tendency of this class of molecule to form acommon packing motif. Crystal structure analysis of 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic diesters andanalogs reveals that they form extended chains, characterizedas the C(6) packing motif, via intermolecular (amine) N—H? ? ?O—C (C3,C5 carbonyl) hydrogen bonds. In addition, allthe prepared derivatives also satisfy the basic structuralrequirements for their high binding efficiency to the receptor.The reproducible C(6) packing motif observed among thesecompounds has a use in the design of solid-state materials.