Acid- and metal-free synthesis of annulated pyrroles in a deep eutectic solvent

摘要

An environmentally benign, one-pot, three component synthesis of annulated pyrroles by coupling free sugars with enamines, generated in situ from aryl amines and 1,3-diketones, has been achieved by using a deep eutectic solvent (DES). The reaction conditions are mild and do not require additional Bronsted or Lewis acid catalysts.