Mesoporous silica coated Gd-2(CO3)(3):Eu hollow nanospheres for simultaneous cell imaging and drug delivery

摘要

In the present work, mesoporous silica coated Gd-2(CO3)(3):Eu hollow nanospheres (Gd-2(CO3)(3):Eu@mSiO(2) HNSs) were successfully synthesized via a facial route and characterized by X-ray diffraction (XRD), transmission electron microscope (TEM), scanning electron microscope (SEM) infrared spectrometer (IR), energy dispersive X-ray spectrum (EDS) and Brunauer-Emmet-Teller (BET) surface area analysis. The results indicate that the prepared monodispersed nanoparticles are hollow spheres with a 400 nm sphere core and 30 nm thick shell and have a narrow size distribution. In vitro cell imaging of the hollow nanosphere shows Gd-2(CO3)(3):Eu@mSiO(2) HNSs were able to enter NCI-H460 lung cancer cells rapidly. The possibility of using the synthesized hollow nanospheres for magnetic resonance imaging was also demonstrated, and the hollow nanosphere displays a clear T-1-weighted effect and could potentially serve as a bimodal T-1-positive contrast agent. The drug loading and controlled release performance of Gd-2(CO3)(3):Eu@mSiO(2) HNSs was evaluated with doxorubicin hydrochloride (DOX) as a model drug at different pH values (pH = 7.4, 5.8). The Gd-2(CO3)(3):Eu@mSiO(2) HNSs showed sustainable pH dependent drug release property. Furthermore, the in vitro cytotoxic effect against NCI-H460 lung cancer cells of the DOX-loaded carriers was investigated in detail. In all, the Gd-2(CO3)(3):Eu@mSiO(2) HNSs as a new type of theragnostic (imaging and treatment) agent can provide new opportunities in cancer treatment.