Opposing Effects of PPARa Agonism and Antagonism on Refractive Development and Form Deprivation Myopia in Guinea Pigs

Pan Miaozhen; Jiao Shiming; Reinach Peter S.; Yan Jiaofeng; Yang Yanan; Li Qihang; Srinivasalu Nethrajeith; Qu Jia; Zhou Xiangtian

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Opposing Effects of PPARa Agonism and Antagonism on Refractive Development and Form Deprivation Myopia in Guinea Pigs

机译：PPARA激动症对豚鼠折射发育及剥夺近视的反对作用

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PURPOSE. To determine if drug-induced peroxisome proliferator-activated receptor alpha (PPAR alpha) signal pathway modulation affects refractive development and myopia in guinea pigs.

机译：目的。为了确定药物诱导的过氧缺血剂增殖剂活化受体α（PPARα）信号途径调制影响豚鼠的屈光发育和近视。

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来源
《Investigative ophthalmology & visual science 》 |2018年第15期| 共13页
作者
Pan Miaozhen; Jiao Shiming; Reinach Peter S.; Yan Jiaofeng; Yang Yanan; Li Qihang; Srinivasalu Nethrajeith; Qu Jia; Zhou Xiangtian;
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作者单位

Wenzhou Med Univ Sch Ophthalmol &

Optometry 270 Xueyuan Rd Wenzhou 325027 Zhejiang Peoples R;

Wenzhou Med Univ Sch Ophthalmol &

Optometry 270 Xueyuan Rd Wenzhou 325027 Zhejiang Peoples R;

Wenzhou Med Univ Sch Ophthalmol &

Optometry 270 Xueyuan Rd Wenzhou 325027 Zhejiang Peoples R;

Wenzhou Med Univ Sch Ophthalmol &

Optometry 270 Xueyuan Rd Wenzhou 325027 Zhejiang Peoples R;

Wenzhou Med Univ Sch Ophthalmol &

Optometry 270 Xueyuan Rd Wenzhou 325027 Zhejiang Peoples R;

Wenzhou Med Univ Sch Ophthalmol &

Optometry 270 Xueyuan Rd Wenzhou 325027 Zhejiang Peoples R;

Wenzhou Med Univ Sch Ophthalmol &

Optometry 270 Xueyuan Rd Wenzhou 325027 Zhejiang Peoples R;

Wenzhou Med Univ Sch Ophthalmol &

Optometry 270 Xueyuan Rd Wenzhou 325027 Zhejiang Peoples R;

Wenzhou Med Univ Sch Ophthalmol &

Optometry 270 Xueyuan Rd Wenzhou 325027 Zhejiang Peoples R;

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原文格式 PDF
正文语种 eng
中图分类眼科学 ;
关键词
guinea pig; myopia; PPARa; GW7647; GW6471; fibrates; ME1; apoA-II;

机译：豚鼠;近视;PPARA;GW7647;GW6471;敌人;ME1;APOA-II;

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专利

1. Opposing Effects of PPARa Agonism and Antagonism on Refractive Development and Form Deprivation Myopia in Guinea Pigs [J] . Pan Miaozhen, Jiao Shiming, Reinach Peter S., Investigative ophthalmology & visual science . 2018 ,第15期

机译：PPARA激动症对豚鼠折射发育及剥夺近视的反对作用
2. Dopamine Receptor Subtypes Mediate Opposing Effects on Form Deprivation Myopia in Pigmented Guinea Pigs [J] . Zhang Sen, Yang Jinglei, Reinach Peter S., Investigative ophthalmology & visual science . 2018 ,第11期

机译：多巴胺受体亚型在着色的豚鼠中调解对相反的作用对剥夺豚鼠的剥夺近视
3. Dopamine Receptor Subtypes Mediate Opposing Effects on Form Deprivation Myopia in Pigmented Guinea Pigs [J] . Sen Zhang, Jinglei Yang, Peter S. Reinach, Investigative ophthalmology & visual science . 2018 ,第11期

机译：多巴胺受体亚型在着色的豚鼠中调解对相反的作用对剥夺豚鼠的剥夺近视
4. Biomechanical properties of experimental myopia in the guinea pig [C] . WANG Xiaojun, CHEN Weiyi, LI Yanjun, The 2nd International Conference on Bioinformatics and Biomedical Engineering(iCBBE 2008)(第二届生物信息与生物医学工程国际会议）论文集 . 2008

机译：实验性近视眼豚鼠的生物力学特性
5. Modeling Myopia in Guinea Pigs [D] . Kochik, Sarah. 2019

机译：在豚鼠中造型近视
6. Changes in protein profiles of guinea pig sclera during development of form deprivation myopia and recovery [O] . Xiangtian Zhou, Juxiu Ye, Mark D.P. Willcox, 2010

机译：形成性剥夺性近视发展过程中豚鼠巩膜蛋白质谱的变化
7. The Effects of High Lighting on the Development of Form-Deprivation Myopia in Guinea Pigs [O] . Luoli Zhang, Xiaomei Qu 2019

机译：高光照明对豚鼠剥夺近视发展的影响

Opposing Effects of PPARa Agonism and Antagonism on Refractive Development and Form Deprivation Myopia in Guinea Pigs

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