遺伝性不整脈疾患研究の現況と展望

摘要

Some patients with inherited cardiac arrhythmias such as congenital long QT syndrome (LQTS) ， Brugada syndrome, and early repolarization syndrome (ERS) have alink to mutations in genes encoding for ion channels or other membrane components. The diagnosis and management for inherited cardiac arrhythmias have been updated in recently published HRS/EHRA/APHRS Expert Consensus Statement. More recently, an exome study or whole genome study by using next generation sequencer as well as a genome-wide association study (GWAS) by using a gene array have been introduced to identify a new responsible gene or to explore the role of common genetic variants (polymorphisms) as a susceptible or modifier gene in inherited cardiac arrhythmias.