Bis-diorganotin(IV) complexes with binucleating hydrazones derived from a methylene-bis-aromatic aldehyde as linker: Synthesis, spectral and structural characterization, antibacterial activity and DNA cleavage studies

摘要

AbstractTwo bis-hydrazone, H4Laand H4Lb, have been synthesized from reaction of 5,5′-methylene-bis-salicylaldehyde with benzhydrazide and furan-2-carbohydrazide, respectively. New organotin(IV) complexes, (R2Sn)2L [L?=?La: R?=?Me (1), Ph (2); L?=?Lb: R?=?Me (3), Ph (4)] have been synthesized by reaction of dihydrazone ligands with R2SnCl2(R?=?Me or Ph). The synthesized compounds have been investigated by elemental analysis and IR,1H NMR, and119Sn NMR spectroscopy. The structures of1and2have been also confirmed by X-ray crystallography. The results show that the dihydrazone acts as a tetrabasic ligand in the enolic form and is coordinated to two SnR2moieties via ONO donor domains by the imine nitrogen and phenolic and enolic oxygen atoms. All complexes are binuclear and the coordination number of both tin is five. Thein?vitroantibacterial activity of ligands and complexes has been evaluated against Gram-positive (Bacillus subtilisandStaphylococcus aureus) and Gram-negative (Escherichia coliandPseudomonas aeruginosa) bacteria and compared with standard drugs. The synthesized compoun