Detection of Atherosclerotic Inflammation by Ga-68-DOTATATE PET Compared to [F-18] FDG PET Imaging

Tarkin Jason M.; Joshi Francis R.; Evans Nicholas R.; Chowdhury Mohammed M.; Figg Nichola L.; Shah Aarti V.; Starks Lakshi T.; Martin-Garrido Abel; Manavaki Roido; Yu Emma; Kuc Rhoda E.; Grassi Luigi; Kreuzhuber Roman; Kostadima Myrto A.; Frontini Mattia; Kirkpatrick Peter J.; Coughlin Patrick A.; Gopalan Deepa; Fryer Tim D.; Buscombe John R.; Groves Ashley M.; Ouwehand Willem H.; Bennett Martin R.; Warburton Elizabeth A.; Davenport Anthony P.; Rudd James H. F.

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Detection of Atherosclerotic Inflammation by Ga-68-DOTATATE PET Compared to [F-18] FDG PET Imaging

机译：与[F-18] FDG PET成像相比，通过GA-68-致催化剂检测甘露粥样硬酸盐蛋白炎症

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BACKGROUND Inflammation drives atherosclerotic plaque rupture. Although inflammation can be measured using fluorine-18-labeled fluorodeoxyglucose positron emission tomography ([F-18] FDG PET), [F-18] FDG lacks cell specificity, and coronary imaging is unreliable because of myocardial spillover.

机译：背景炎症驱动动脉粥样硬化斑块破裂。尽管可以使用氟-18标记的氟脱氧氧葡萄糖正电子发射断层扫描（[F-18] FDG PET）测量炎症，但是[F-18] FDG缺乏细胞特异性，并且由于心肌溢出，冠状动脉成像是不可靠的。

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来源
《Journal of the American College of Cardiology 》 |2017年第14期| 共18页
作者
Tarkin Jason M.; Joshi Francis R.; Evans Nicholas R.; Chowdhury Mohammed M.; Figg Nichola L.; Shah Aarti V.; Starks Lakshi T.; Martin-Garrido Abel; Manavaki Roido; Yu Emma; Kuc Rhoda E.; Grassi Luigi; Kreuzhuber Roman; Kostadima Myrto A.; Frontini Mattia; Kirkpatrick Peter J.; Coughlin Patrick A.; Gopalan Deepa; Fryer Tim D.; Buscombe John R.; Groves Ashley M.; Ouwehand Willem H.; Bennett Martin R.; Warburton Elizabeth A.; Davenport Anthony P.; Rudd James H. F.;
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作者单位

Univ Cambridge Div Cardiovasc Med Cambridge England;

Rigshosp Heart Ctr Copenhagen Denmark;

Univ Cambridge Dept Clin Neurosci Cambridge England;

Addenbrookes Hosp Dept Vasc &

Endovasc Surg Cambridge England;

Univ Cambridge Div Cardiovasc Med Cambridge England;

Univ Cambridge Div Cardiovasc Med Cambridge England;

Univ Cambridge Div Cardiovasc Med Cambridge England;

Univ Cambridge Div Cardiovasc Med Cambridge England;

Univ Cambridge Dept Radiol Cambridge England;

Univ Cambridge Div Cardiovasc Med Cambridge England;

Univ Cambridge Expt Med &

Immunotherapeut Cambridge England;

Univ Cambridge Dept Hematol Cambridge Biomed Campus Cambridge England;

Univ Cambridge Dept Hematol Cambridge Biomed Campus Cambridge England;

Univ Cambridge Dept Hematol Cambridge Biomed Campus Cambridge England;

Univ Cambridge Dept Hematol Cambridge Biomed Campus Cambridge England;

Addenbrookes Hosp Div Neurosurg Cambridge England;

Addenbrookes Hosp Dept Vasc &

Endovasc Surg Cambridge England;

Univ Cambridge Dept Radiol Cambridge England;

Univ Cambridge Dept Clin Neurosci Cambridge England;

Addenbrookes Hosp Dept Nucl Med Cambridge England;

UCL Inst Nucl Med London England;

Univ Cambridge Dept Hematol Cambridge Biomed Campus Cambridge England;

Univ Cambridge Div Cardiovasc Med Cambridge England;

Univ Cambridge Dept Clin Neurosci Cambridge England;

Univ Cambridge Expt Med &

Immunotherapeut Cambridge England;

Univ Cambridge Div Cardiovasc Med Cambridge England;

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正文语种 eng
中图分类心脏、血管（循环系）疾病 ;
关键词
atherosclerosis; inflammation; macrophages; molecular imaging; positron emission tomography; somatostatin receptor;

机译：动脉粥样硬化;炎症;巨噬细胞;分子成像;正电子发射断层扫描;生长抑素受体;

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专利

1. Detection of Atherosclerotic Inflammation by Ga-68-DOTATATE PET Compared to [F-18] FDG PET Imaging [J] . Tarkin Jason M., Joshi Francis R., Evans Nicholas R., Journal of the American College of Cardiology . 2017 ,第14期

机译：与[F-18] FDG PET成像相比，通过GA-68-致催化剂检测甘露粥样硬酸盐蛋白炎症
2. Lesions of multiple myeloma adjacent to the skull are better visualized on F-18 fluoroethyldimethyl-2-hydroxyethylammonium (FECH) PET images than on F-18 FDG PET images. [J] . Cheng X, Cui R, Li F, Clinical nuclear medicine . 2011 ,第10期

机译：与F-18 FDG PET图像相比，在F-18氟乙基二甲基-2-羟乙基铵（FECH）PET图像上可以更好地看到邻近颅骨的多发性骨髓瘤的病变。
3. 18F-FDG PET and intravascular ultrasonography (IVUS) images compared with histology of atherosclerotic plaques: 18F-FDG accumulates in foamy macrophages [J] . IshinoS., OgawaM., MoriI., European Journal of Nuclear Medicine and Molecular Imaging . 2014 ,第4期

机译：18F-FDG PET和血管内超声（IVUS）图像与动脉粥样硬化斑块的组织学比较：18F-FDG积聚在泡沫巨噬细胞中
4. Very low-dose adult whole-body tumor imaging with F-18 FDG PET/CT [C] . Andrzej Krol, Muhammad Naveed, Mary McGrath, Conference on biomedical applications in molecular, structural, and functional imaging . 2015

机译：F-18 FDG PET / CT超低剂量成人全身肿瘤成像
5. Response Assessment and Prediction in Esophageal Cancer Patients via F-18 FDG PET/CT Scans. [D] . Higgins, Kyle J. 2015

机译：通过F-18 FDG PET / CT扫描对食道癌患者进行反应评估和预测。
6. Detection of Atherosclerotic Inflammation by 68Ga-DOTATATE PET Compared to 18FFDG PET Imaging [O] . Jason M. Tarkin, Francis R. Joshi, Nicholas R. Evans, -1

机译：与18F FDG PET成像相比通过68Ga-DOTATATE PET检测动脉粥样硬化炎症
7. Non-invasive imaging of atherosclerotic plaque macrophage in a rabbit model with F-18 FDG PET: a histopathological correlation [O] . Zhuangyu Zhang, Josef Machac, Gerard Helft, 2006

机译：F-18 FDG PET兔模型中动脉粥样硬化斑块巨噬细胞的非侵入性成像：组织病理学相关性

Detection of Atherosclerotic Inflammation by Ga-68-DOTATATE PET Compared to [F-18] FDG PET Imaging

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