Repeated-dose 26-week oral toxicity study of ginsenoside compound K in Beagle dogs

Li Chunmei; Wang Zhezhe; Wang Tong; Wang Guangfei; Li Guisheng; Sun Chengfeng; Lin Jian; Sun Liqin; Sun Xilin; Cho Susan; Wang Hongbo; Gao Yonglin; Tian Jingwei

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Repeated-dose 26-week oral toxicity study of ginsenoside compound K in Beagle dogs

机译：猎犬犬人参皂苷类化合物K的重复剂量26周的口服毒性研究

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Ethnopharmacological relevance: Ginsenoside compound K (CK), a product produced by the intestinal bacteria-mediated breakdown of ginsenoside, exhibits a wide array of pharmacological activities against diverse targets. However, few of preclinical safety evaluation of CK is reported.

机译：民族科医药相关性：人参皂苷复合K（CK），由肠道细菌介导的人参皂苷分解产生的产物，呈现出针对各种靶标的各种药理活动。然而，报告了CK的临床前安全评估。

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来源
《Journal of Ethnopharmacology: An Interdisciplinary Journal Devoted to Bioscientific Research on Indigenous Drugs》 |2020年第2020期|共8页
作者
Li Chunmei; Wang Zhezhe; Wang Tong; Wang Guangfei; Li Guisheng; Sun Chengfeng; Lin Jian; Sun Liqin; Sun Xilin; Cho Susan; Wang Hongbo; Gao Yonglin; Tian Jingwei;
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作者单位

Yantai Univ Collaborat Innovat Ctr Adv Drug Delivery Syst &

B Key Lab Mol Pharmacol &

Drug;

Yantai Univ Collaborat Innovat Ctr Adv Drug Delivery Syst &

B Key Lab Mol Pharmacol &

Drug;

Yantai Univ Sch Life Sci 30 Qingquan RD Laishan Dist 264005 Yantai Peoples R China;

Yantai Univ Collaborat Innovat Ctr Adv Drug Delivery Syst &

B Key Lab Mol Pharmacol &

Drug;

Yantai Univ Collaborat Innovat Ctr Adv Drug Delivery Syst &

B Key Lab Mol Pharmacol &

Drug;

Yantai Univ Sch Life Sci 30 Qingquan RD Laishan Dist 264005 Yantai Peoples R China;

Yantai Univ Sch Life Sci 30 Qingquan RD Laishan Dist 264005 Yantai Peoples R China;

Yantai Univ Sch Life Sci 30 Qingquan RD Laishan Dist 264005 Yantai Peoples R China;

Yantai Laishan Changen Hosp Yantai 264005 Peoples R China;

NutraSource Inc Clarksville MD 21029 USA;

Yantai Univ Collaborat Innovat Ctr Adv Drug Delivery Syst &

B Key Lab Mol Pharmacol &

Drug;

Yantai Univ Sch Life Sci 30 Qingquan RD Laishan Dist 264005 Yantai Peoples R China;

Yantai Univ Collaborat Innovat Ctr Adv Drug Delivery Syst &

B Key Lab Mol Pharmacol &

Drug;

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原文格式 PDF
正文语种 eng
中图分类药理学;
关键词
Ginsenoside compound K; Oral toxicity study; Preclinical safety evaluation; Beagle dogs;

机译：人参皂苷类化合物K;口服毒性研究;临床前安全评估;比格犬;

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专利

1. Repeated-dose 26-week oral toxicity study of ginsenoside compound K in Beagle dogs [J] . Li Chunmei, Wang Zhezhe, Wang Tong, Journal of Ethnopharmacology: An Interdisciplinary Journal Devoted to Bioscientific Research on Indigenous Drugs . 2020,第期

机译：猎犬犬人参皂苷类化合物K的重复剂量26周的口服毒性研究
2. Toxicity of a novel anti-tumor agent 20(S)-ginsenoside Rg3: a 26-week intramuscular repeated administration study in Beagle dogs. [J] . Liu JP, Lu D, Nicholson RC, Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research . 2011,第8期

机译：新型抗肿瘤药20（S）-人参皂苷Rg3的毒性：在Beagle犬中进行的为期26周的肌肉内重复给药研究。
3. 26-week repeated oral dose toxicity study of UP446, a combination of defined extracts of Scutellaria baicalensis and Acacia catechu, in beagle dogs [J] . Yimam Mesfin, Lee Young Chul, Jia Qi Regulatory Toxicology and Pharmacology: RTP . 2016,第Null期

机译：UP446（黄S和阿拉伯树胶特有提取物的组合）在比格犬中进行的26周重复口服剂量毒性研究
4. Preliminary Evaluation of Procedure for the Gamma Scintigraphic Study of Behaviour of Oral DosageForms in the Gastrointestinal Tract of Beagle Dogs [C] . Fiona McInnes, Howard Stevens, Michael Humphrey, Annual meeting exposition of the Controlled Release Society . 2005

机译：对比格犬胃肠道口服剂型行为的伽马闪烁显像研究程序的初步评估
5. Accelerated Orthodontic Tooth Movement With Flapless Corticotomy: A Pilot Study in Beagle Dogs. [D] . Hao, Jianjun. 2011

机译：无瓣皮瓣切开术加速牙齿正畸运动：比格犬的一项初步研究。
6. Acute and repeated dose 26-week oral toxicity study of 20(S)-ginsenoside Rg3 in Kunming mice and Sprague–Dawley rats [O] . Chunmei Li, Zhezhe Wang, Guisheng Li, 2020

机译：昆明小鼠和Sprague-Dawley大鼠对20（S）-人参皂苷Rg3的急性和重复剂量26周口服毒性研究
7. Acute and repeated dose 26-week oral toxicity study of 20(S)-ginsenoside Rg3 in Kunming mice and Sprague–Dawley rats [O] . Chunmei Li, Zhezhe Wang, Guisheng Li, 2020

机译：昆明小鼠和Sprague-Dawley大鼠20（S）-Ginsenide RG3的急性和重复剂量26周的口服毒性研究
8. Toxicity Studies on Compound Nsc 61487, Carbonic Acid, Bis(P-Aminophenyl)Ester, Dihydrochloride Following Repeated Doses in Beagle Dogs and Rhesus Monkeys: Some Comparative Studies in Dogs Using Compound Nsc 1545, p-Aminophenol, Hcl [R] . Rakieten, N., Schein, P. S., Davis, R. D. 1967

机译：复方Nsc 61487，碳酸，双（对氨基苯）酯，二盐酸盐在Beagle犬和恒河猴反复给药后的毒性研究：使用化合物Nsc 1545，对氨基苯酚，Hcl的狗的一些比较研究

Repeated-dose 26-week oral toxicity study of ginsenoside compound K in Beagle dogs

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