Second harmonic generation microscopy as a tool for the early detection of crystallization in spray dried dispersions

摘要

Highlights ? Second harmonic generation (SHG) microscopy was applied for sensitive detection of crystallinity in spray dried particles. ? SHG detected crystallinity at an earlier time point than X-ray powder diffraction for two spray dried sytems. ? The SHG technique presented herein can be potentially used to rapidly evaluate the stability of different spray dried formulations to crystallization. Abstract Various techniques have been used to detect crystallization in amorphous solid dispersions (ASD). However, most of these techniques do not enable the detection of very low levels of crystallinity (