Synthesis, structures and biological activity of novel complexes with trifluorinated anthranilic acid derivatives

摘要

Two cobalt complexes [Co-2(L)(phen)(Ac)(PLC)] (1), [Co-3(HL)(4)(CH3O)(2)(H2O)(2)] (2) and one zinc complex [Zn-2(L)(phen)(Ac)( PLC)] (3), (L = (2-carboxylato-5-(trifluoromethyl)phenyl) (3-hyd roxy-4-methoxyphenoxy)amide, phen = 1,10-phenanthroline, Ac = acetate, PLC = 2-amino-4- trifluoromethylbenzoate) have been synthesized and characterized by physicochemical and spectroscopic methods. In addition, X-ray crystallography shows that the Co and Zn atoms in each complex are penta- or six-coordinated, adopting a twisted square pyramid or triangular bi-conical geometry. The antitumor activity of complex against A549 (human lung cancer cells) and Hela (human cervical cancer cells) was screened. Results show that 3 exhibits the most effective antitumor activity (IC50 = 1.369-2.129 mu M). Antimicrobial studies also show that 3 exhibits the highest activity. (C) 2019 Elsevier B.V. All rights reserved.