Molecular interaction studies of antibiotic drug Doxycycline Hyclate with aqueous mannitol using volumetric and acoustic methods

摘要

The behaviour of Doxycycline Hyclate (DH) in aqueous mannitol solution was studied to explore molecular interactions at different temperatures. The volumetric and acoustic studies were used for investigating the interactions of drug Doxycycline Hyclate in water and aqueous mannitol system. The Density (rho) and ultrasonic velocity (u) of Doxycycline Hyclate in water and in (0.1, 0.2 and 0.4) mol.kg(-1) aqueous solutions of mannitol have been measured at (305.15, 310.15 and 315.15 K) temperatures and atmospheric pressure. The density data was analysed with the help of Masson's equation. The positive value of (phi(0)(v)) for DH indicates solute solvent interactions The solute-solute interactions were determined from Masson's coefficient, (S-v) in water-mannitol system at different temperatures. The ultrasonic velocity data of DH in water and water-mannitol system were used to determine adiabatic compressibility (beta), intermolecular free length (L-f), and specific acoustic impedance (Z). The structure making/breaking behaviour of DH in water and water mannitol system is determined on the basis of Hepler's equation. The UV spectra for DH in water and water-mannitol system stand in support of molecular interactions between drug and mannitol. (C) 2016 Published by Elsevier B.V.