Combined cerium oxide nanocapping and layer-by-layer coating of porous silicon containers for controlled drug release

摘要

Local drug release in close vicinity of solid tumors is a promising therapeutic approach in cancer therapy. Implantable drug delivery systems can be designed to achieve controlled and sustained drug release. In this study, ultrathin porous membranes of silicon wafer were employed as compatible drug reservoir models. An anticancer model drug, curcumin (CUR), was successfully loaded into porous silicon containers (8.94 +/- 0.72% w/w), and then, cerium oxide nanocapping was performed on the open pores for drug protection and release rate prolongation. Next, layer-by-layer surface coating of the drug container with anionic (alginate) and cationic (chitosan) polymers rendered pH-responsivity to the device. The drug release profile was studied using reflectometric interference Fourier transform spectroscopy at different pH conditions. It was determined that faster decomposition of the polymeric layers and subsequent CUR release occur in acidic buffer (pH 5.5) compared to a neutral buffer. Various characterization studies, including dynamic light scattering, Fourier transform infrared spectroscopy, scanning and transmission electron microscopy, contact angle measurement, ultraviolet-visible spectroscopy, and X-ray powder diffraction revealed that our system has the required physicochemical properties to serve as a novel pH-sensitive drug delivery implant for cancer therapy.