Comment on 'Determination and Thermodynamic Modeling of Solid-Liquid Phase Equilibrium for Esomeprazole Sodium in Monosolvents and in the (Ethanol plus Ethyl Acetate) Binary Solvent Mixtures'

摘要

Errors are found in several of the mathematical representations in the published paper by Zhao and co-workers. Published curve-fit parameters for several of the modified Apelblat model representations yield back-calculated mole fraction solubilities of esomeprazole sodium that exceed unity. Mole fraction concentrations cannot exceed unity. Back-calculated mole fraction solubilities for a mathematical representation, presumably based on the Jouyban Acree model, were also found to exceed unity.