Lynch syndrome in patients with colorectal cancer: Finding the needle in the haystack

摘要

IDENTIFICATION OF INDIVIDUALS AT INCREASED RISK OF HE-reditary cancer allows for the possibility of screening and early cancer detection, possibly resulting in decreased disease-specific mortality, and is the justification for germline genetic testing for specific cancer risk alleles. However, factors of prevalence and age-specific penetrance, effectiveness and in-vasiveness of screening procedures, and efficacy of early detection influence the potential benefit of such an approach.