A general strategy to add diversity to ruthenium arene complexes with bioactive organic compounds via a coordinated (4-hydroxyphenyl) diphenylphosphine ligand

摘要

Esterification of (4-hydroxyphenyl)diphenylphosphine, coordinated to the [Ru(eta(6)-p-cymene)Cl-2] fragment, allows a series of bioactive carboxylic acids to be introduced directly into the organometallic molecule. Evaluation of the compounds on human ovarian cancer cells reveals synergistic enhancements in their anti-proliferative activity relative to their bioactive organic and organometallic precursors.