Disentangling the genetics of lean mass

Karasik David; Zillikens M. Carola; Hsu Yi-Hsiang; Aghdassi Ali; Akesson Kristina; Amin Najaf; Barroso Ines; Bennett David A.; Bertram Lars; Bochud Murielle; Borecki Ingrid B.; Broer Linda; Buchman Aron S.; Byberg Liisa; Campbell Harry; Campos-Obando Natalia; Cauley Jane A.; Cawthon Peggy M.; Chambers John C.; Chen Zhao; Cho Nam H.; Choi Hyung Jin; Chou Wen-Chi; Cummings Steven R.; de Groot Lisette C. P. G. M.; De Jager Phillip L.; Demuth Ilja; Diatchenko Luda; Econs Michael J.; Eiriksdottir Gudny; Enneman Anke W.; Eriksson Joel; Eriksson Johan G.; Estrada Karol; Evans Daniel S.; Feitosa Mary F.; Fu Mao; Gieger Christian; Grallert Harald; Gudnason Vilmundur; Lenore Launer J.; Hayward Caroline; Hofman Albert; Homuth Georg; Huffman Kim M.; Husted Lise B.; Illig Thomas; Ingelsson Erik; Ittermann Till; Jansson John-Olov; Johnson Toby; Biffar Reiner; Jordan Joanne M.; Jula Antti; Karlsson Magnus; Khaw Kay-Tee; Kilpelainen Tuomas O.; Klopp Norman; Kloth Jacqueline S. L.; Koller Daniel L.; Kooner Jaspal S.; Kraus William E.; Kritchevsky Stephen; Kutalik Zoltan; Kuulasmaa Teemu; Kuusisto Johanna; Laakso Markku; Lahti Jari; Lang Thomas; Langdahl Bente L.; Lerch Markus M.; Lewis Joshua R.; Lill Christina; Lind Lars; Lindgren Cecilia; Liu Yongmei; Livshits Gregory; Ljunggren Osten; Loos Ruth J. F.; Lorentzon Mattias; Luan Jianan; Luben Robert N.; Malkin Ida; McGuigan Fiona E.; Medina-Gomez Carolina; Meitinger Thomas; Melhus Hakan; Mellstrom Dan; Michaelsson Karl; Mitchell Braxton D.; Morris Andrew P.; Mosekilde Leif; Nethander Maria; Newman Anne B.; OConnell Jeffery R.; Oostra Ben A.; Orwoll Eric S.; Palotie Aarno; Peacock Munro; Perola Markus; Peters Annette; Prince Richard L.; Psaty Bruce M.; Raikkonen Katri; Ralston Stuart H.; Ripatti Samuli; Rivadeneira Fernando; Robbins John A.; Rotter Jerome I.; Rudan Igor; Salomaa Veikko; Satterfield Suzanne; Schipf Sabine; Shin Chan Soo; Smith Albert V.; Smith Shad B.; Soranzo Nicole; Spector Timothy D.; Stancakova Alena; Stefansson Kari; Steinhagen-Thiessen Elisabeth; Stolk Lisette; Streeten Elizabeth A.; Styrkarsdottir Unnur; Swart Karin M. A.; Thompson Patricia; Thomson Cynthia A.; Thorleifsson Gudmar; Thorsteinsdottir Unnur; Tikkanen Emmi; Tranah Gregory J.; Uitterlinden Andre G.; van Duijn Cornelia M.; van Schoor Natasja M.; Vandenput Liesbeth; Vollenweider Peter; Volzke Henry; Wactawski-Wende Jean; Walker Mark; Wareham Nicholas J.; Waterworth Dawn; Weedon Michael N.; Wichmann H-Erich; Widen Elisabeth; Williams Frances M. K.; Wilson James F.; Wright Nicole C.; Yerges-Armstrong Laura M.; Yu Lei; Zhang Weihua; Zhao Jing Hua; Zhou Yanhua; Nielson Carrie M.; Harris Tamara B.; Demissie Serkalem; Kiel Douglas P.; Ohlsson Claes

首页> 外文期刊>The American Journal of Clinical Nutrition: Official Journal of the American Society for Clinical Nutrition >Disentangling the genetics of lean mass

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Disentangling the genetics of lean mass

机译：解开精益群众的遗传

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Background: Lean body mass (LM) plays an important role in mobility and metabolic function. We previously identified five loci associated with LM adjusted for fat mass in kilograms. Such an adjustment may reduce the power to identify genetic signals having an association with both lean mass and fat mass.

机译：背景：瘦体重（LM）在移动性和代谢功能中起重要作用。我们之前鉴定了与LM相关的五个基因座，用于千克脂肪质量。这种调整可以降低能力以识别具有与贫质量和脂肪质量的关联的遗传信号。

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《The American Journal of Clinical Nutrition: Official Journal of the American Society for Clinical Nutrition》 |2019年第2期|共12页
作者
Karasik David; Zillikens M. Carola; Hsu Yi-Hsiang; Aghdassi Ali; Akesson Kristina; Amin Najaf; Barroso Ines; Bennett David A.; Bertram Lars; Bochud Murielle; Borecki Ingrid B.; Broer Linda; Buchman Aron S.; Byberg Liisa; Campbell Harry; Campos-Obando Natalia; Cauley Jane A.; Cawthon Peggy M.; Chambers John C.; Chen Zhao; Cho Nam H.; Choi Hyung Jin; Chou Wen-Chi; Cummings Steven R.; de Groot Lisette C. P. G. M.; De Jager Phillip L.; Demuth Ilja; Diatchenko Luda; Econs Michael J.; Eiriksdottir Gudny; Enneman Anke W.; Eriksson Joel; Eriksson Johan G.; Estrada Karol; Evans Daniel S.; Feitosa Mary F.; Fu Mao; Gieger Christian; Grallert Harald; Gudnason Vilmundur; Lenore Launer J.; Hayward Caroline; Hofman Albert; Homuth Georg; Huffman Kim M.; Husted Lise B.; Illig Thomas; Ingelsson Erik; Ittermann Till; Jansson John-Olov; Johnson Toby; Biffar Reiner; Jordan Joanne M.; Jula Antti; Karlsson Magnus; Khaw Kay-Tee; Kilpelainen Tuomas O.; Klopp Norman; Kloth Jacqueline S. L.; Koller Daniel L.; Kooner Jaspal S.; Kraus William E.; Kritchevsky Stephen; Kutalik Zoltan; Kuulasmaa Teemu; Kuusisto Johanna; Laakso Markku; Lahti Jari; Lang Thomas; Langdahl Bente L.; Lerch Markus M.; Lewis Joshua R.; Lill Christina; Lind Lars; Lindgren Cecilia; Liu Yongmei; Livshits Gregory; Ljunggren Osten; Loos Ruth J. F.; Lorentzon Mattias; Luan Jianan; Luben Robert N.; Malkin Ida; McGuigan Fiona E.; Medina-Gomez Carolina; Meitinger Thomas; Melhus Hakan; Mellstrom Dan; Michaelsson Karl; Mitchell Braxton D.; Morris Andrew P.; Mosekilde Leif; Nethander Maria; Newman Anne B.; OConnell Jeffery R.; Oostra Ben A.; Orwoll Eric S.; Palotie Aarno; Peacock Munro; Perola Markus; Peters Annette; Prince Richard L.; Psaty Bruce M.; Raikkonen Katri; Ralston Stuart H.; Ripatti Samuli; Rivadeneira Fernando; Robbins John A.; Rotter Jerome I.; Rudan Igor; Salomaa Veikko; Satterfield Suzanne; Schipf Sabine; Shin Chan Soo; Smith Albert V.; Smith Shad B.; Soranzo Nicole; Spector Timothy D.; Stancakova Alena; Stefansson Kari; Steinhagen-Thiessen Elisabeth; Stolk Lisette; Streeten Elizabeth A.; Styrkarsdottir Unnur; Swart Karin M. A.; Thompson Patricia; Thomson Cynthia A.; Thorleifsson Gudmar; Thorsteinsdottir Unnur; Tikkanen Emmi; Tranah Gregory J.; Uitterlinden Andre G.; van Duijn Cornelia M.; van Schoor Natasja M.; Vandenput Liesbeth; Vollenweider Peter; Volzke Henry; Wactawski-Wende Jean; Walker Mark; Wareham Nicholas J.; Waterworth Dawn; Weedon Michael N.; Wichmann H-Erich; Widen Elisabeth; Williams Frances M. K.; Wilson James F.; Wright Nicole C.; Yerges-Armstrong Laura M.; Yu Lei; Zhang Weihua; Zhao Jing Hua; Zhou Yanhua; Nielson Carrie M.; Harris Tamara B.; Demissie Serkalem; Kiel Douglas P.; Ohlsson Claes;
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Hebrew Senior Life Inst Aging Res Boston MA USA;

Erasmus MC Dept Internal Med Rotterdam Netherlands;

Hebrew Senior Life Inst Aging Res Boston MA USA;

Ernst Moritz Arndt Univ Greifswald Dept Med A Greifswald Germany;

Lund Univ Dept Clin Sci Malmo Malmo Sweden;

Erasmus MC Dept Epidemiol Rotterdam Netherlands;

Wellcome Trust Sanger Inst Wellcome Trust Genome Campus Hinxton England;

Rush Univ Med Ctr Rush Alzheimers Dis Ctr Chicago IL 60612 USA;

Univ Lubeck Lubeck Interdisciplinary Platform Genome Analyt Lubeck Germany;

Lausanne Univ Hosp Univ Inst Social &

Prevent Med Lausanne Switzerland;

Washington Univ Dept Genet Div Stat Gen Sch Med St Louis MO 63110 USA;

Erasmus MC Dept Internal Med Rotterdam Netherlands;

Rush Univ Med Ctr Rush Alzheimers Dis Ctr Chicago IL 60612 USA;

Uppsala Univ Dept Surg Sci Uppsala Sweden;

Univ Edinburgh Usher Inst Populat Hlth Sci &

Informat Ctr Global Hlth Res Teviot Pl Edinburgh;

Erasmus MC Dept Internal Med Rotterdam Netherlands;

Univ Pittsburgh Grad Sch Publ Hlth Dept Epidemiol Pittsburgh PA 15260 USA;

Calif Pacific Med Ctr Res Inst San Francisco CA USA;

Ealing Hosp NHS Trust Cardiol London England;

Univ Arizona Mel &

Enid Zuckerman Coll Publ Hlth Tucson AZ USA;

Ajou Univ Sch Med Dept Prevent Med Suwon South Korea;

Seoul Natl Univ Coll Med Dept Internal Med Seoul South Korea;

Hebrew Senior Life Inst Aging Res Boston MA USA;

Calif Pacific Med Ctr Res Inst San Francisco CA USA;

Columbia Univ Med Ctr Ctr Translat &

Computat Neuroimmunol Neurol New York NY USA;

Broad Inst Cell Circuits Program Cambridge MA USA;

Berlin Inst Hlth Berlin Germany;

Univ North Carolina Chapel Hill Sch Dent Reg Ctr Neurosensory Disorders Chapel Hill NC USA;

Indiana Univ Sch Med Dept Med Indianapolis IN 46202 USA;

Iceland Heart Assoc Holtasmari Kopavogur Iceland;

Erasmus MC Dept Internal Med Rotterdam Netherlands;

Univ Gothenburg Sahlgrenska Acad Inst Med Dept Internal Med &

Clin Nutr Gothenburg Sweden;

Natl Inst Hlth &

Welfare Helsinki Finland;

Erasmus MC Dept Internal Med Rotterdam Netherlands;

Calif Pacific Med Ctr Res Inst San Francisco CA USA;

Washington Univ Dept Genet Div Stat Gen Sch Med St Louis MO 63110 USA;

Univ Maryland Sch Med Div Endocrinol Diabet &

Nutr Program Personalized &

Genom Med Baltimore;

Helmholtz Zentrum Munchen German Res Ctr Environm Hlth Res Unit Mol Epidemiol Neuherberg Germany;

Helmholtz Zentrum Munchen German Res Ctr Environm Hlth Res Unit Mol Epidemiol Neuherberg Germany;

Iceland Heart Assoc Holtasmari Kopavogur Iceland;

NIA Lab Epidemiol &

Populat Sci Intramural Res Program Bethesda MD 20892 USA;

Univ Edinburgh MRC Human Genet Unit IGMM Edinburgh Midlothian Scotland;

Erasmus MC Dept Internal Med Rotterdam Netherlands;

Ernst Moritz Arndt Univ Greifswald Interfac Inst Genet &

Funct Gen Greifswald Germany;

Duke Univ Sch Med Dept Med Duke Mol Physiol Inst Durham NC 27706 USA;

Aarhus Univ Hosp Endocrinol &

Internal Med Aarhus Denmark;

Helmholtz Zentrum Munchen German Res Ctr Environm Hlth Res Unit Mol Epidemiol Neuherberg Germany;

Stanford Univ Sch Med Dept Med Div Cardiovasc Med Stanford CA USA;

Ernst Moritz Arndt Univ Greifswald Inst Community Med Greifswald Germany;

Univ Gothenburg Sahlgrenska Acad Inst Neurosci &

Physiol Dept Physiol Gothenburg Sweden;

Lausanne Univ Hosp Univ Inst Social &

Prevent Med Lausanne Switzerland;

Ernst Moritz Arndt Univ Greifswald Dept Prosthet Dent Gerodontol &

Biomat Ctr Oral Hlth;

Univ North Carolina Chapel Hill Thurston Arthrit Res Ctr Chapel Hill NC USA;

Natl Inst Hlth &

Welfare Helsinki Finland;

Skane Univ Hosp Dept Orthoped Malmo Sweden;

Univ Cambridge Dept Publ Hlth &

Primary Care Cambridge England;

Univ Cambridge MRC Epidemiol Unit Sch Clin Med Cambridge Biomed Campus Cambridge England;

Helmholtz Zentrum Munchen German Res Ctr Environm Hlth Res Unit Mol Epidemiol Neuherberg Germany;

Erasmus MC Dept Internal Med Rotterdam Netherlands;

Indiana Univ Sch Med Dept Med Indianapolis IN 46202 USA;

Ealing Hosp NHS Trust Cardiol London England;

Duke Univ Sch Med Dept Med Duke Mol Physiol Inst Durham NC USA;

Wake Forest Sch Med Sticht Ctr Hlth Aging &

Alzheimers Prevent Winston Salem NC USA;

Lausanne Univ Hosp Univ Inst Social &

Prevent Med Lausanne Switzerland;

Univ Eastern Finland Dept Med Kuopio Finland;

Univ Eastern Finland Dept Med Kuopio Finland;

Univ Eastern Finland Dept Med Kuopio Finland;

Univ Helsinki Helsinki Collegium Adv Studies Helsinki Finland;

UC San Francisco Dept Radiol &

Biomed Imaging San Francisco CA USA;

Aarhus Univ Hosp Endocrinol &

Internal Med Aarhus Denmark;

Ernst Moritz Arndt Univ Greifswald Dept Med A Greifswald Germany;

Univ Western Australia Sch Med &

Pharmacol Perth WA Australia;

Univ Lubeck Inst Neurogenet Lubeck Germany;

Uppsala Univ Dept Med Sci Uppsala Sweden;

Univ Oxford Wellcome Trust Ctr Human Genet Oxford England;

Wake Forest Sch Med Dept Epidemiol &

Prevent Winston Salem NC USA;

Tel Aviv Univ Dept Anat &

Anthropol Sackler Fac Med Tel Aviv Israel;

Uppsala Univ Dept Med Sci Uppsala Sweden;

Icahn Sch Med Mt Sinai Dept Environm Med &

Publ Hlth New York NY USA;

Univ Gothenburg Sahlgrenska Acad Inst Med Dept Internal Med Gothenburg Sweden;

Icahn Sch Med Mt Sinai Dept Environm Med &

Publ Hlth New York NY USA;

Univ Copenhagen Fac Hlth &

Med Sci Sect Metabol Genet Novo Nordisk Fdn Ctr Basic Metab Res;

Tel Aviv Univ Dept Anat &

Anthropol Sackler Fac Med Tel Aviv Israel;

Lund Univ Dept Clin Sci Malmo Malmo Sweden;

Erasmus MC Dept Internal Med Rotterdam Netherlands;

Tech Univ Munich Inst Human Genet MRI Munich Germany;

Uppsala Univ Dept Med Sci Uppsala Sweden;

Univ Gothenburg Sahlgrenska Acad Inst Med Dept Internal Med &

Clin Nutr Gothenburg Sweden;

Lund Univ Dept Clin Sci Malmo Malmo Sweden;

Univ Maryland Sch Med Div Endocrinol Diabet &

Nutr Program Personalized &

Genom Med Baltimore;

Univ Oxford Wellcome Trust Ctr Human Genet Oxford England;

Aarhus Univ Hosp Endocrinol &

Internal Med Aarhus Denmark;

Univ Gothenburg Sahlgrenska Acad Inst Med Dept Internal Med &

Clin Nutr Gothenburg Sweden;

Univ Pittsburgh Grad Sch Publ Hlth Dept Epidemiol Pittsburgh PA 15260 USA;

Univ Maryland Sch Med Div Endocrinol Diabet &

Nutr Program Personalized &

Genom Med Baltimore;

Erasmus MC Dept Clin Genet Rotterdam Netherlands;

Oregon Hlth &

Sci Univ Portland OR USA;

Univ Helsinki Inst Mol Med Finland Helsinki Finland;

Indiana Univ Sch Med Dept Med Indianapolis IN 46202 USA;

Natl Inst Hlth &

Welfare Helsinki Finland;

Helmholtz Zentrum Munchen German Res Ctr Environm Hlth Res Unit Mol Epidemiol Neuherberg Germany;

Univ Western Australia Sch Med &

Pharmacol Perth WA Australia;

Univ Washington Dept Med Cardiovasc Hlth Res Unit Seattle WA USA;

Univ Helsinki Dept Psychol &

Logoped Helsinki Finland;

Harvard Med Sch Boston MA 02115 USA;

Wellcome Trust Sanger Inst Wellcome Trust Genome Campus Hinxton England;

Erasmus MC Dept Internal Med Rotterdam Netherlands;

Univ Calif Davis Dept Med Sacramento CA 95817 USA;

Harbor UCLA Med Ctr Inst Translat Genom &

Populat Sci Los Angeles Biomed Res Inst Torrance CA;

Univ Pittsburgh Grad Sch Publ Hlth Dept Epidemiol Pittsburgh PA 15260 USA;

Natl Inst Hlth &

Welfare Helsinki Finland;

Univ Tennessee Ctr Hlth Sci Dept Prevent Med Memphis TN 38163 USA;

Ernst Moritz Arndt Univ Greifswald Inst Community Med Greifswald Germany;

Seoul Natl Univ Coll Med Dept Internal Med Seoul South Korea;

Iceland Heart Assoc Holtasmari Kopavogur Iceland;

Duke Univ Dept Anesthesiol Ctr Translat Pain Med Durham NC USA;

Wellcome Trust Sanger Inst Wellcome Trust Genome Campus Hinxton England;

Kings Coll London Dept Twin Res &

Genet Epidemiol St Thomas Campus London England;

Univ Eastern Finland Dept Med Kuopio Finland;

Univ Iceland Fac Med Reykjavik Iceland;

Harvard Sch Publ Hlth Mol &

Integrat Physiol Sci Program Boston MA USA;

Erasmus MC Dept Internal Med Rotterdam Netherlands;

Univ Maryland Sch Med Div Endocrinol Diabet &

Nutr Program Personalized &

Genom Med Baltimore;

deCODE Genet Reykjavik Iceland;

Vrije Univ Amsterdam Med Ctr Dept Epidemiol &

Biostat Amsterdam Netherlands;

Univ Arizona Mel &

Enid Zuckerman Coll Publ Hlth Tucson AZ USA;

deCODE Genet Reykjavik Iceland;

Univ Iceland Fac Med Reykjavik Iceland;

Natl Inst Hlth &

Welfare Helsinki Finland;

Calif Pacific Med Ctr Res Inst San Francisco CA USA;

Erasmus MC Dept Internal Med Rotterdam Netherlands;

Erasmus MC Dept Epidemiol Rotterdam Netherlands;

Vrije Univ Amsterdam Med Ctr Dept Epidemiol &

Biostat Amsterdam Netherlands;

Univ Gothenburg Sahlgrenska Acad Inst Med Dept Internal Med &

Clin Nutr Gothenburg Sweden;

Lausanne Univ Hosp Dept Med Internal Med Lausanne Switzerland;

Erasmus MC Dept Internal Med Rotterdam Netherlands;

Univ Buffalo SUNY Dept Epidemiol &

Environm Hlth Buffalo NY USA;

Newcastle Univ Med Sch Inst Cellular Med Diabetes Framlington Pl Newcastle Upon Tyne Tyne &

Univ Cambridge MRC Epidemiol Unit Sch Clin Med Cambridge Biomed Campus Cambridge England;

GlaxoSmithKline Genet King Of Prussia PA USA;

Univ Exeter Med Sch Royal Devon &

Exeter Hosp Genet Complex Traits Exeter Devon England;

Helmholtz Zentrum Munchen German Res Ctr Environm Hlth Inst Epidemiol 2 Neuherberg Germany;

Univ Helsinki Inst Mol Med Finland Helsinki Finland;

Kings Coll London Dept Twin Res &

Genet Epidemiol St Thomas Campus London England;

Univ Edinburgh Usher Inst Populat Hlth Sci &

Informat Ctr Global Hlth Res Teviot Pl Edinburgh;

Univ Alabama Birmingham Dept Epidemiol Birmingham AL USA;

Univ Maryland Sch Med Div Endocrinol Diabet &

Nutr Program Personalized &

Genom Med Baltimore;

Rush Univ Med Ctr Rush Alzheimers Dis Ctr Chicago IL 60612 USA;

Ealing Hosp NHS Trust Cardiol London England;

Univ Cambridge MRC Epidemiol Unit Sch Clin Med Cambridge Biomed Campus Cambridge England;

Boston Univ Sch Publ Hlth Dept Biostat Boston MA USA;

Oregon Hlth &

Sci Univ Portland OR USA;

NIA Lab Epidemiol &

Populat Sci Intramural Res Program Bethesda MD 20892 USA;

Boston Univ Sch Publ Hlth Dept Biostat Boston MA USA;

Hebrew Senior Life Inst Aging Res Boston MA USA;

Univ Gothenburg Sahlgrenska Acad Inst Med Dept Internal Med &

Clin Nutr Gothenburg Sweden;

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原文格式 PDF
正文语种 eng
中图分类营养卫生、食品卫生;
关键词
body composition; skeletal muscle; body fat; meta-analysis of genome-wide association studies; metabolic profile;

机译：身体成分;骨骼肌;体脂;荟萃分析基因组关联研究;代谢概况;

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Disentangling the genetics of lean mass

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