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首页> 外文期刊>Current opinion in immunology >HLA class I antigen expression in malignant cells: why does it not always correlate with CTL-mediated lysis?
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HLA class I antigen expression in malignant cells: why does it not always correlate with CTL-mediated lysis?

机译:HLA I类抗原在恶性细胞中的表达:为什么它不总是与CTL介导的裂解相关?

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摘要

HLA class I antigen defects are frequently found in malignant cells. They appear to play a role in the clinical course of the disease, probably because they provide tumor cells with a mechanism to escape cytotoxic T lymphocyte (CTL) recognition and destruction. Expression of HLA class I antigens, however, is not always associated with the susceptibility of tumor cells to CTL lysis. Many mechanisms may underlie this finding, including the lack of tumor antigen (TA)-derived peptide presentation by a given HLA class I allospecificity, and/or the expression of immunosuppressive molecules such as HLA-G. These findings emphasize the need to develop probes to measure HLA class I allospecificity-TA peptide complex expression in malignant cells. Furthermore, the evaluation of the role of HLA class I antigens in the interaction of malignant cells with host immune cells should take into account the potential interference of tumor-derived immunomodulators.
机译:HLA I类抗原缺陷经常在恶性细胞中发现。它们似乎在疾病的临床过程中起作用,可能是因为它们为肿瘤细胞提供了逃避细胞毒性T淋巴细胞(CTL)识别和破坏的机制。但是,HLA I类抗原的表达并不总是与肿瘤细胞对CTL裂解的敏感性相关。许多发现可能是这一机制的基础,包括缺乏给定的HLA I类同种异体特异性的肿瘤抗原(TA)衍生肽,和/或免疫抑制分子(例如HLA-G)的表达。这些发现强调需要开发探针以测量恶性细胞中HLA I类同种特异性-TA肽复合物的表达。此外,HLA I类抗原在恶性细胞与宿主免疫细胞相互作用中的作用评估应考虑到肿瘤衍生免疫调节剂的潜在干扰。

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