Copper(II)-Mediated Chelation-Assisted Regioselective N-Naphthylation of Indoles, Pyrazoles and Pyrrole through Dehydrogenative Cross-Coupling

摘要

src="http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/joceah/2017/joceah.2017.82.issue-9/acs.joc.7b00615/20170501/images/medium/jo-2017-00615y_0013.gif">A copper-mediated picolinamide directed regioselective cross-coupling of naphthylamines with azoles is developed via C–H functionalization and C–N bond formation. The reaction of indoles leads to the formation of chiral C–N cross-coupled products with functional group tolerance. These reaction conditions can also be extended to the cross-coupling of pyrazole and pyrrole scaffolds.