Alkali-Induced Ring-Opening of 2-Amidodihydrofuran and Manganese-Catalyzed Aerobic Dehydrogenation Annulation: Access?to Functionalized Oxazole

摘要

src="http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/joceah/2017/joceah.2017.82.issue-9/acs.joc.7b00112/20170501/images/medium/jo-2017-00112d_0011.gif">A novel and efficient synthesis of functionalized oxazoles from 2-amidodihydrofurans has been achieved by alkali-induced intramolecular C–O bond cleavage and formation using air as a green oxidant. Moreover, these functionalized oxazoles could be readily transformed into the corresponding oxazole-substituted pyrazoles and 2H-azirines.