Synthesis of 3-Arylbenzofuran-2-ylphosphines via Rhodium Catalyzed Redox-Neutral C-H Activation and Their Applications in Palladium-Catalyzed Cross-Coupling of Aryl Chlorides

摘要

A new class of aryl-heteroarylphosphines, 3-arylbenzofuran-2-ylphosphines, was synthesized by [Cp*Rh(111)1-catalyzed redox-neutral cyclization of N-phenoxyacetamides with 1-alkynylphosphine sulfides and oxides followed by reduction. This step-economic reaction proceeds in excellent regioselectivity with a broad substrate scope. The application of the resulting air-stable trivalent-phosphine containing dicyclo-hexylphosphino moiety in palladium-catalyzed Suzuki Miyaura coupling and Buchwald Hartwig amination of aryl chlorides is also described.