Total Synthesis of (+)-Guadinomic Acid via Hydroxyl-Directed Guanidylation

摘要

Protecting-group-free total synthesis of (+)-guadinomic acid is reported using S-valerolactone as a readily available starting material. The protocol utilizes the recent hydroxyl directed guanidylation of unactivated alkenes as an approach for direct stereoselective incorporation of the guanidine unit furnishing the natural product in 7 steps.