Electrochemical Synthesis Strategy for C-vinyl-CF3 Compounds through Decarboxylative Trifluoromethylation

摘要

An efficient decarboxylative trifluoromethylation of alpha,beta-unsaturated carboxylic acids using the Langlois reagent as a trifluoromethyl precursor has been achieved by an electro-oxidative strategy. Under catalyst-free and external oxidant-free electrolysis conditions, a series of C-vinyl-CF3 compounds are obtained with a high regioselectivity in good yields. The successful trapping of the CF3 radical by a scavenger has confirmed that radical processes are involved in this system.