Cp*Ir(III)-Catalyzed C-H/O-H Functionalization of Salicylaldehydes for the Synthesis of Chromones at Room Temperature

摘要

Herein, we report Cp*Ir(III)-catalyzed C-H/O-H-bond functionalization of salicylaldehydes with alpha-diazocarbonyl compounds for the synthesis of chromones under redox-neutral conditions. The reaction proceeds at room temperature and displays excellent functional group tolerance along with high yields of the corresponding products. The developed reaction protocol was successfully applied for the late-stage functionalization of estrone derivative.