Statin-induced myopathy in a competitive amateur cyclist.

摘要

The HMG-CoA reductase inhibitors, also known as statins, are highly effective and safe lipid-lowering agents, used by 100 million people worldwide. The most common side effects are muscle pain and weakness, occurring in roughly 5%-7% of patients. Discontinuation of the medication is usually adequate treatment, and the symptoms resolve in a few weeks. However, they are not well-studied in active individuals or athletes, where the stress of training may amplify the side effects. The following case report reviews the experience of one elite amateur cyclist and his prolonged course of myalgia and fatigue following the use of a statin medication. The natural history of this disorder, possible pathophysiology, and treatment guidelines will be discussed. Statins may not be the best choice for lipid-lowering in this subset of the population.