Lewis acid catalyst system for Claisen-Schmidt reaction under solvent free condition

摘要

Ca(OTf)(2) in combination with NBu4 center dot BF4 was established to function as an efficient catalyst system for one-pot Claisen-Schmidt condensation under neat conditions. Substituted acetophenones and benzaldehydes were coupled in situ to afford their corresponding chalcones in excellent yields. The method, with a broad range of substrate tolerance and mild operational conditions can produce assorted chalcone derivatives in moderate to high yields from easily accessible starting materials. (C) 2020 Elsevier Ltd. All rights reserved.