The bicyclo[2.1.1]hexan-2-one system: a new probe for the experimental and computational study of electronic effects in #pi#-facial selectivity in nucleophilic additions

摘要

The remotely substituted 5-exo-bicyclo[2.1.1]hexan-2-one system is introduced as a new probe to study long range electronic effects on #pi#-face selectivity during hydride reduction and a systematic computational studydemonstrates good predictability at the semi-empirical level.