Accessing substituted pyrrolidines via formal [3+2] cycloaddition of 1,3,5-triazinanes and donor-acceptor cyclopropanes

摘要

The formal [3+2] cycloaddition of 1,3,5-triaryl-1,3,5-triazinanes with donor-acceptor cyclopropanes has been found to provide pyrrolidines in good to excellent yields under mild reaction conditions. Preliminary mechanistic investigation indicates that this formal [3+2] cycloaddition reaction proceeds through competing S(N)1 and S(N)2 pathways. (C) 2018 Elsevier Ltd. All rights reserved.