Synthesis of polycyclic scaffolds via a gold-catalysed dearomative cyclisation cascade

摘要

Polycyclic scaffolds found in akuammiline alkaloid natural products can be synthesised from ynonetethered indoles, via a gold(I)-catalysed dearomative cyclisation cascade sequence. The ynone starting materials are themselves made via a two-step modular synthesis from simple tryptamine and tryptophol derivatives. (C) 2020 Elsevier Ltd. All rights reserved.