phenylselenoethers as Precursors of Acyclic Free Radicals. Creating Tertiary and Quaternary Centers Using Free Radical-Based Intermediates

摘要

Selenium-based methods have developed rapidly over the past few years and certain features of chiral selenium-containing compounds make these reagents particularly valuable for efficient stereoselective reactions.Recent advances in stereoselective transformations involving one-pot selenenylation-deselenylation sequences,which occur using only catalytic amounts of the optically active diselenides in the synthesis of valuable building blocks will be summarized.Additionally,recent results of catalytic reactions using chiral selenides and diselenides such as the enantioselective copper catalyzed conjugate addition of organometallic reagents to enones,diorganozinc addition to aldehydes,palladium-catalyzed enantioselective ally lic alkylation,among other topics will also be addressed.