Potent Half-Sandwich Iridium(III) and Ruthenium(II) Anticancer Complexes Containing a P^O-Chelated Ligand

Qing Du; Lihua Guo; Meng Tian; Xingxing Ge; Yuliang Yang; Xiyan Jian; Zhishan Xu; Zhenzhen Tian; Zhe Liu

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Potent Half-Sandwich Iridium(III) and Ruthenium(II) Anticancer Complexes Containing a P^O-Chelated Ligand

机译：有效的半三明治铱（III）和钌（II）抗癌复合物，含有P ^ O螯合配体

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机译：<！[CDATA [我们在此报告了一系列铱（III）和钌（II）的合成，表征和抗癌活性[（CP〜（x）/ arene）m（p ^ O）Cl] PF_（6）（M = IR，CP〜（x）=五甲基环戊二烯基（CP *）或其苯基（CP〜（XPH）= C_（5）ME_（4）C_（6）H_（5）（CP〜（Xbiph）= C_（5）Me_（4）C_（6）H_（4）C_（6）H_（5））衍生物; M = Ru，arene = p-cymene（ p-cym）; P ^ o =膦膦酰胺配体（PPOA））。确定了所有配合物的X射线晶体结构，其中配体可以与金属中心形成六元环。所有复合体都表现出令人瞩目的抗癌活动，朝Hela和A549癌细胞，高于临床抗癌药物顺铂的活动。掺入铱（III）复合物的CP *环上的苯基取代基导致它们的抗癌活动几乎没有变化。这些结果可归因于金属和PPOA配体的组合作用。水解和DNA裂解不是主要的作用机制。这些配合物在NADH的转移氢化至NAD〜（+）中显示出有效的催化活性。另外，复合物[（η〜（5）-C_（5）ME_（5））IR（P ^ O）CL] PF_（6）（ 1）和[（η〜（6） - P-CYM）CL] PF_（6）（ 4）分别在S和G_（2）/ m相和S期的抑制细胞循环。复合物 1和 4都可以诱导Hela癌细胞的凋亡。还进行了活性氧物质（ROS）和线粒体膜电位测试以探讨作用机制。当复合物的浓度增加时，活性氧物质（ROS）的量显着增加，线粒体膜电位在Hela癌细胞中显着降低。总体而言，细胞应力包括细胞周期扰动，细胞凋亡诱导，ROS水平的增加，并且线粒体膜势的丧失有助于这些配合物的抗癌效力。有趣的是，使用c

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《Organometallics》 |2018年第17期|共10页
作者
Qing Du; Lihua Guo; Meng Tian; Xingxing Ge; Yuliang Yang; Xiyan Jian; Zhishan Xu; Zhenzhen Tian; Zhe Liu;
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Institute of Anticancer Agents Development and Theranostic Application The Key Laboratory of Life-Organic Analysis and Key Laboratory of Pharmaceutical Intermediates and Analysis of Natural Medicine Department of Chemistry and Chemical Engineering Qufu;

Institute of Anticancer Agents Development and Theranostic Application The Key Laboratory of Life-Organic Analysis and Key Laboratory of Pharmaceutical Intermediates and Analysis of Natural Medicine Department of Chemistry and Chemical Engineering Qufu;

Institute of Anticancer Agents Development and Theranostic Application The Key Laboratory of Life-Organic Analysis and Key Laboratory of Pharmaceutical Intermediates and Analysis of Natural Medicine Department of Chemistry and Chemical Engineering Qufu;

Institute of Anticancer Agents Development and Theranostic Application The Key Laboratory of Life-Organic Analysis and Key Laboratory of Pharmaceutical Intermediates and Analysis of Natural Medicine Department of Chemistry and Chemical Engineering Qufu;

Institute of Anticancer Agents Development and Theranostic Application The Key Laboratory of Life-Organic Analysis and Key Laboratory of Pharmaceutical Intermediates and Analysis of Natural Medicine Department of Chemistry and Chemical Engineering Qufu;

Institute of Anticancer Agents Development and Theranostic Application The Key Laboratory of Life-Organic Analysis and Key Laboratory of Pharmaceutical Intermediates and Analysis of Natural Medicine Department of Chemistry and Chemical Engineering Qufu;

Institute of Anticancer Agents Development and Theranostic Application The Key Laboratory of Life-Organic Analysis and Key Laboratory of Pharmaceutical Intermediates and Analysis of Natural Medicine Department of Chemistry and Chemical Engineering Qufu;

Institute of Anticancer Agents Development and Theranostic Application The Key Laboratory of Life-Organic Analysis and Key Laboratory of Pharmaceutical Intermediates and Analysis of Natural Medicine Department of Chemistry and Chemical Engineering Qufu;

Institute of Anticancer Agents Development and Theranostic Application The Key Laboratory of Life-Organic Analysis and Key Laboratory of Pharmaceutical Intermediates and Analysis of Natural Medicine Department of Chemistry and Chemical Engineering Qufu;

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1. Potent Half-Sandwich Iridium(III) and Ruthenium(II) Anticancer Complexes Containing a P^O-Chelated Ligand [J] . Qing Du, Lihua Guo, Meng Tian, Organometallics . 2018,第17期

机译：有效的半三明治铱（III）和钌（II）抗癌复合物，含有P ^ O螯合配体
2. Serendipitous Synthesis of Five-Coordinated Half-Sandwich Aminoimine Iridium(III) and Ruthenium(II) Complexes and Their Application as Potent Anticancer Agents [J] . Du Qing, Guo Lihua, Ge Xingxing, Inorganic Chemistry: A Research Journal that Includes Bioinorganic, Catalytic, Organometallic, Solid-State, and Synthetic Chemistry and Reaction Dynamics . 2019,第9期

机译：偶然合成五分 - 夹心氨基亚氨基氨基亚氨基氨基铱（III）和钌（II）复合物及其作为强效抗癌剂的应用
3. Potent Half-Sandwich Iridium(III) Anticancer Complexes Containing C∧N-Chelated and Pyridine Ligands [J] . Zhe Liu, Isolda Romero-Canelo?n, Abraha Habtemariam, Organometallics . 2014,第19期

机译：包含C∧N螯合和吡啶配体的强半三明治铱（III）抗癌复合物
4. Synthesis of Phenylpyridine Iridium(III) Complexes with N-Heterocyclic Carbene as Ancillary Ligands [C] . N H A Bain, N M Ali, Y Juahir International Fundamentum Science Symposium . 2019

机译：用N-杂环烷烃作为辅助配体的合成苯吡啶铱（III）配合物
5. Synthesis and chemistry of iridium complexes containing chiral diphosphine ligands: Oxidative addition to iridium(I) systems and catalytic activity of the electrophilic iridium(III) complexes. [D] . Atesin, Abdurrahman Cagri. 2008

机译：含手性二膦配体的铱配合物的合成与化学：铱（I）系统的氧化加成和亲电铱（III）配合物的催化活性。
6. Potent Half-Sandwich Iridium(III) Anticancer ComplexesContaining C∧N-Chelated and Pyridine Ligands [O] . Zhe Liu, §, Isolda Romero-Canelón, -1

机译：强力半三明治铱（III）抗癌复合物含有C∧N螯合和吡啶配体
7. Potent half-sandwich iridium(III) anticancer complexes containing C∧N-Chelated and pyridine ligands [O] . Liu, Zhe, Romero-Canelón, Isolda, Habtemariam, Abraha, 2014

机译：含有C∧N螯合和吡啶配体的强力半三明治铱（III）抗癌复合物

Potent Half-Sandwich Iridium(III) and Ruthenium(II) Anticancer Complexes Containing a P^O-Chelated Ligand

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