Gene expression of T3-regulated genes in a mouse model of the human thyroid hormone resistance

Santiago L. A.; Faustino L. C.; Pereira G. F.; Imperio G. E.; Pazos-Moura C. C.; Wondisford F. E.; Bloise F. F.; Ortiga-Carvalho T. M.

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Gene expression of T3-regulated genes in a mouse model of the human thyroid hormone resistance

机译：T3调节基因在人甲状腺激素抗性小鼠模型中T3调节基因的基因表达

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Aims: To understand how thyroid hormone (TH) regulates tissue-specific gene expression in patients with the syndrome of resistance to TH (RTH beta), we used a mouse model that replicates the human RTH beta, specifically the 6,337T mutation in the thyroid hormone receptor beta (THR beta).

机译：目的：要了解甲状腺激素（Th）如何调节患者对抗性患者的组织特异性基因表达（第Rβ），我们使用了一种复制人Rthβ的小鼠模型，特别是甲状腺中的6,337T突变激素受体β（thrβ）。

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来源
《Life sciences》 |2017年第2017期|共7页
作者
Santiago L. A.; Faustino L. C.; Pereira G. F.; Imperio G. E.; Pazos-Moura C. C.; Wondisford F. E.; Bloise F. F.; Ortiga-Carvalho T. M.;
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作者单位

Univ Fed Rio de Janeiro Inst Biofis Carlos Chagas Filho Lab Endocrinol Translac Gss16 Carlos;

Univ Fed Rio de Janeiro Inst Biofis Carlos Chagas Filho Lab Endocrinol Translac Gss16 Carlos;

Univ Fed Rio de Janeiro Inst Biofis Carlos Chagas Filho Lab Endocrinol Translac Gss16 Carlos;

Univ Fed Rio de Janeiro Inst Biofis Carlos Chagas Filho Lab Endocrinol Translac Gss16 Carlos;

Univ Fed Rio de Janeiro Inst Biofis Carlos Chagas Filho Lab Endocrinol Mol Rio De Janeiro RJ;

Rutgers Robert Wood Johnson Med Sch Dept Med New Brunswick NJ USA;

Univ Fed Rio de Janeiro Inst Biofis Carlos Chagas Filho Lab Endocrinol Translac Gss16 Carlos;

Univ Fed Rio de Janeiro Inst Biofis Carlos Chagas Filho Lab Endocrinol Translac Gss16 Carlos;

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原文格式 PDF
正文语种 eng
中图分类医药、卫生;
关键词
Thyroid hormone receptor; Gene expression; Liver;

机译：甲状腺激素受体;基因表达;肝脏;

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专利

1. Gene expression of T3-regulated genes in a mouse model of the human thyroid hormone resistance [J] . Santiago L. A., Faustino L. C., Pereira G. F., Life sciences . 2017,第期

机译：T3调节基因在人甲状腺激素抗性小鼠模型中T3调节基因的基因表达
2. Thyroid hormones directly activate the expression of the human and mouse uncoupling protein-3 genes through a thyroid response element in the proximal promoter region [J] . Antonio VIDAL-PUIG, Bradford?B. LOWELL, Francesc VILLARROYA, The biochemical journal . 2005,第3期

机译：甲状腺激素通过近端启动子区域中的甲状腺反应元件直接激活人和小鼠解偶联蛋白3基因的表达
3. Thyroid hormones directly activate the expression of the human and mouse uncoupling protein-3 genes through a thyroid response element in the proximal promoter region [J] . Solanes G, Pedraza N, Calvo V, The Biochemical Journal . 2005,第Pta3期

机译：甲状腺激素通过近端启动子区域中的甲状腺反应元件直接激活人和小鼠解偶联蛋白3基因的表达
4. The Hormone Response Element (HRE) of the Human ApoCIII Enhancer Is Essential for the Intestinal Expression of the Human Apoa-I Gene in Transgenic Mice [C] . Horng Yuan Kan, Spiros Georgopoulos, Eleni Zanni, NATO Advanced Study Institute on Vascular Endothelium : Mechanisms of Cell Signaling . 1999

机译：人Apociii Enhancer的激素应答元件（HRE）对于转基因小鼠中人Apoa-I基因的肠道表达至关重要
5. Dietary modulation of tumorigenesis and gene expression in the Min mouse, a genetic model for human colorectal cancer. [D] . Mridvika. 2001

机译：日粮对人类小鼠大肠癌的遗传模型Min小鼠的肿瘤发生和基因表达的饮食调节。
6. Multi-tissue gene-expression analysis in a mouse model of thyroid hormone resistance [O] . Lance D Miller, Peter McPhie, Hideyo Suzuki, 2004

机译：小鼠甲状腺激素抵抗模型中的多组织基因表达分析
7. Multi-tissue gene-expression analysis in a mouse model of thyroid hormone resistance [O] . 2004

机译：小鼠甲状腺激素抵抗模型中的多组织基因表达分析

Gene expression of T3-regulated genes in a mouse model of the human thyroid hormone resistance

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