Luteolin synergizes the antitumor effects of 5-fluorouracil against human hepatocellular carcinoma cells through apoptosis induction and metabolism

Xu Huanli; Yang Tao; Liu Xiaohui; Tian Ye; Chen Xiaoliang; Yuan Ru; Su Shuonan; Lin Xiukun; Du Guanhua

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Luteolin synergizes the antitumor effects of 5-fluorouracil against human hepatocellular carcinoma cells through apoptosis induction and metabolism

机译：虎蛋白通过凋亡诱导和代谢来协同5-氟尿嘧啶对人肝细胞癌细胞的抗肿瘤效应

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Aims: Some compounds derived from Chinese medicine have demonstrated great prospective roles in sensitization to chemotherapy. This study aimed to investigate the combination of luteolin and 5-fluorouracil on proliferations of hepatocellular carcinoma cells and the potential mechanisms.

机译：目的：源自中医的一些化合物表明了对化疗致敏的巨大前瞻性作用。本研究旨在探讨叶黄素和5-氟尿嘧啶对肝细胞癌细胞增殖和潜在机制的组合。

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来源
《Life sciences》 |2016年第1期|共10页
作者
Xu Huanli; Yang Tao; Liu Xiaohui; Tian Ye; Chen Xiaoliang; Yuan Ru; Su Shuonan; Lin Xiukun; Du Guanhua;
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作者单位

Capital Med Univ Sch Basic Med Sci Dept Pharmacol Beijing 100069 Peoples R China;

Chinese Acad Med Sci Inst Mat Med Natl Ctr Pharmaceut Screening Beijing 100050 Peoples R China;

Capital Med Univ Sch Basic Med Sci Dept Pharmacol Beijing 100069 Peoples R China;

Capital Med Univ Sch Basic Med Sci Dept Pharmacol Beijing 100069 Peoples R China;

Capital Med Univ Sch Basic Med Sci Dept Pharmacol Beijing 100069 Peoples R China;

Capital Med Univ Sch Basic Med Sci Dept Pharmacol Beijing 100069 Peoples R China;

Capital Med Univ Sch Basic Med Sci Dept Pharmacol Beijing 100069 Peoples R China;

Capital Med Univ Sch Basic Med Sci Dept Pharmacol Beijing 100069 Peoples R China;

Chinese Acad Med Sci Inst Mat Med Natl Ctr Pharmaceut Screening Beijing 100050 Peoples R China;

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原文格式 PDF
正文语种 eng
中图分类医药、卫生;
关键词
5-Fluorouracil; Luteolin; Synergistic effect; Apoptosis; Hepatocellular carcinoma;

机译：5-氟尿嘧啶;叶黄素;协同效应;细胞凋亡;肝细胞癌;

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专利

1. Luteolin synergizes the antitumor effects of 5-fluorouracil against human hepatocellular carcinoma cells through apoptosis induction and metabolism [J] . Xu Huanli, Yang Tao, Liu Xiaohui, Life sciences . 2016,第1期

机译：虎蛋白通过凋亡诱导和代谢来协同5-氟尿嘧啶对人肝细胞癌细胞的抗肿瘤效应
2. Scutellaria barbata D. Don extract synergizes the antitumor effects of low dose 5-fluorouracil through induction of apoptosis and metabolism [J] . XuH., YuJ., SunY., Phytomedicine : . 2013,第10期

机译：半枝莲D.唐提取物通过诱导细胞凋亡和新陈代谢来协同小剂量5-氟尿嘧啶的抗肿瘤作用
3. 2-Methoxyjuglone induces apoptosis in HepG2 human hepatocellular carcinoma cells and exhibits in vivo antitumor activity in a H22 mouse hepatocellular carcinoma model. [J] . Yu HengYi, Zhang XiaoQiong, Li Xue, Journal of natural products . 2013,第5期

机译：2-甲氧基juglone诱导人类HepG2肝细胞癌细胞凋亡，并在H22小鼠肝细胞癌模型中表现出体内抗肿瘤活性。
4. Induction of G2/M phase arrest and apoptosis by potent antitumor thirty-two-8-oxo-8H-acenaphtho1,2-bpyrrole-9-carbonitrile derivative in human cervix carcinoma cells [C] . rn, rn, rn Asian Pacific Confederation of Chemical Engineering congress . 2008

机译：强效抗肿瘤三十二-8-氧-8H-ac 1,2-b吡咯-9-腈衍生物在人宫颈癌细胞中诱导G2 / M期阻滞和凋亡
5. The anti-cancer activities of Paeoniae Radix extracts on human hepatocellular carcinoma cell-line HepG2 and multidrug resistant human hepatocellular carcinoma cell-line R-HepG2 and their action mechanisms. [D] . Li, Lok Yee Mandy. 2004

机译：e药提取物对人肝癌细胞HepG2和多药耐药人肝癌细胞R-HepG2的抗癌活性及其作用机制。
6. Expression of TNF-related apoptosis-inducing Ligand receptors and antitumor tumor effects of TNF-related apoptosis-inducing Ligand in human hepatocellular carcinoma [O] . Xiao-Ping Chen, Song-Qing He, Hai-Ping Wang, 2003

机译：肿瘤坏死因子相关凋亡诱导配体受体的表达及其在人肝细胞癌中的抗肿瘤作用
7. Morusin shows potent antitumor activity for human hepatocellular carcinoma in vitro and in vivo through apoptosis induction and angiogenesis inhibition [O] . Ling Gao, Li Wang, Zhen Sun, 2017

机译：Morusin通过细胞凋亡诱导和血管生成抑制显示体外和体内人类肝细胞癌有效的抗肿瘤活性

Luteolin synergizes the antitumor effects of 5-fluorouracil against human hepatocellular carcinoma cells through apoptosis induction and metabolism

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