Down-regulation of GR alpha expression and inhibition of its nuclear translocation by hypoxia

摘要

Aims: Glucocorticoids are the most effective anti-inflammatory agent in treating pulmonary diseases typically accompanied by hypoxia. Our previous study has demonstrated that glucocorticoid receptor alpha (GR alpha) expression is reduced in hypoxia but the underlying mechanism remains elusive. In this study we aim to identify the signaling pathway involved in hypoxia-induced down-regulation of GR alpha, and whether hypoxia affects nuclear translocation of GR alpha.