Zinc supplementation alleviates OTA-induced oxidative stress and apoptosis in MDCK cells by up-regulating metallothioneins

Li Hu; Malyar Rahmani Mohammad; Zhai Nianhui; Wang Hong; Liu Kai; Liu Dandan; Pan Cuiling; Can Fang; Huang Kehe; Miao Jinfeng; Chen Xingxiang

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Zinc supplementation alleviates OTA-induced oxidative stress and apoptosis in MDCK cells by up-regulating metallothioneins

机译：通过Up-Consemate Metallothioneins减轻了ota诱导的oTA诱导的氧化胁迫和细胞凋亡

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Aims: The present study was to investigate the protective effects of Zn supplementation in OTA-induced apoptosis of Madin-Darby canine kidney (MDCK) epithelial cells and explore the potential mechanisms. Aiming to provides a new insight into the treatment strategy of OTA-induced nephrotoxicity by nutritional regulation.

机译：目的：本研究是探讨Zn补充在OTA诱导的Madin-Darby犬肾（MDCK）上皮细胞凋亡中的保护作用，并探索潜在机制。旨在通过营养调节提供对OTA诱导的肾毒性治疗策略的新洞察。

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来源
《Life sciences 》 |2019年第2019期| 共10页
作者
Li Hu; Malyar Rahmani Mohammad; Zhai Nianhui; Wang Hong; Liu Kai; Liu Dandan; Pan Cuiling; Can Fang; Huang Kehe; Miao Jinfeng; Chen Xingxiang;
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作者单位

Nanjing Agr Univ Coll Vet Med Nanjing 210095 Jiangsu Peoples R China;

Nanjing Agr Univ Coll Vet Med Nanjing 210095 Jiangsu Peoples R China;

Nanjing Agr Univ Coll Vet Med Nanjing 210095 Jiangsu Peoples R China;

Nanjing Agr Univ Coll Vet Med Nanjing 210095 Jiangsu Peoples R China;

Nanjing Agr Univ Coll Vet Med Nanjing 210095 Jiangsu Peoples R China;

Nanjing Agr Univ Coll Vet Med Nanjing 210095 Jiangsu Peoples R China;

Nanjing Agr Univ Coll Vet Med Nanjing 210095 Jiangsu Peoples R China;

Nanjing Agr Univ Coll Vet Med Nanjing 210095 Jiangsu Peoples R China;

Nanjing Agr Univ Coll Vet Med Nanjing 210095 Jiangsu Peoples R China;

Nanjing Agr Univ Coll Vet Med Nanjing 210095 Jiangsu Peoples R China;

Nanjing Agr Univ Coll Vet Med Nanjing 210095 Jiangsu Peoples R China;

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原文格式 PDF
正文语种 eng
中图分类医药、卫生 ;
关键词
Zinc; Ochratoxin A; Apoptosis; Metallothioneins; MDCK cells;

机译：锌;ochratoxin a;凋亡;金属硫蛋白;mdck细胞;

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专利

1. Zinc supplementation alleviates OTA-induced oxidative stress and apoptosis in MDCK cells by up-regulating metallothioneins [J] . Li Hu, Malyar Rahmani Mohammad, Zhai Nianhui, Life sciences . 2019 ,第期

机译：通过Up-Consemate Metallothioneins减轻了ota诱导的oTA诱导的氧化胁迫和细胞凋亡
2. Zinc supplementation attenuates metallothionein and oxidative stress changes in kidney of streptozotocin-induced diabetic rats [J] . Biological trace element research . 2012 ,第1a3期

机译：补锌可减轻链脲佐菌素致糖尿病大鼠肾脏的金属硫蛋白和氧化应激变化
3. AAV9-IGF1 protects TDP-25 cells from apoptosis and oxidative stress partly via up-regulating the expression of VEGF in vitro [J] . Li Zhongyao, Duan Weisong, Cui Can, Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences . 2017 ,第期

机译：AAV9-IGF1通过在体外提升VEGF的表达，部分保护来自细胞凋亡和氧化应激的TDP-25细胞
4. Zinc, Metallothioneins, and Longevity Effect of Zinc Supplementation:Zincage Study [C] . EUGENIO MOCCHEGIANI, ROBERTINA GIACCONI, CATIA CIPRIANO, International Association of Biomedical Gerontology . 2007

机译：锌，金属噻吩和锌补充剂的寿命效果：锌研究
5. Effects of marginal zinc deficiency and zinc supplementation on lead toxicity, metallothionein and skeletal development in growing rats. [D] . Jamieson, Jennifer Annette. 2006

机译：边际锌缺乏和补锌对成年大鼠铅毒性，金属硫蛋白和骨骼发育的影响。
6. The Zinc-Metallothionein Redox System Reduces Oxidative Stress in Retinal Pigment Epithelial Cells [O] . Sara Rodríguez-Menéndez, Montserrat García, Beatriz Fernández, 2018

机译：锌-金属硫蛋白氧化还原系统减少视网膜色素上皮细胞的氧化应激
7. In vitrofolate supplementation alleviates oxidative stress, mitochondria-associated death signalling and apoptosis induced by 7-ketocholesterol [O] . R.-F. S. Huang, H.-C. Yaong, S.-C. Chen, 2004

机译：在玻璃酸盐补充中，减轻了通过7-酮化合物诱导的氧化应激，线粒体相关的死亡信号传导和凋亡

Zinc supplementation alleviates OTA-induced oxidative stress and apoptosis in MDCK cells by up-regulating metallothioneins

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