Fucoidan protects against subacute diazinon-induced oxidative damage in cardiac, hepatic, and renal tissues

摘要

Fucoidans (FUC) are organic sulfated polysaccharides from natural seaweeds with multiple biological actions. The current study was performed to assess the chemoprotective, antioxidant, and anti-inflammatory effects of FUC from Laminaria japonicum against diazinon (DZN)-induced injuries to rat cardiac, hepatic, and renal tissues. Forty male Wistar rats were assigned into five groups, receiving saline, oral FUC 200?mg/kg/day, subcutaneous DZN 20?mg/kg/day, DZN plus FUC 100?mg/kg/day, or DZN plus FUC 200?mg/kg/day (each treatment was given daily for 4?weeks). Data analysis showed that DZN-intoxicated rats exhibited significantly higher (p?