Delivering Actives via Solid Lipid Nanoparticles and Nanostructured Lipid Carriers: Part IV, Percutaneous Absorption and Dermal Cosmetic Formulations

摘要

Percutaneous absorption is strongly dependent upon the physicochemical properties of the active ingredient applied to skin-i.e., molecular weight (MW), liposolubility and octanol/ water partition coefficient-and on the type and properties of the delivering vehicle. When this vehicle is based on lipid nanoparticulates, enhanced permeation has been reported. SLNs and NLCs are typical nanoparticulate carriers composed of physiological and biodegradable lipids. These carriers were reviewed in Parts I, II and III of this series, with respect to chemical content, production techniques and physicochemical characterization. The present installment, Part IV, discusses the percutaneous absorption of actives loaded into SLNs and NLCs and their formulation in dermal cosmetics. This series will be expanded to include anadditional Part V, which will focus on the rheological and texture analysis of lipid nanoparticles.