Synthesis of Thiadiazole and Azetidinone Derivatives Derived from Triazoles

摘要

A series of novel thiadiazole and azetidinone derivatives of triazole nucleus were synthesized by the sequence of reactions with conventional and microwave techniques. The microwave technique is very useful with excellent yield at less reaction time compare to other conventional methods. The microwave synthesis of titled compound have been successfully performed in these conditions using environmentally friendly method with high atom economy. These compounds identified and characterized by physical and spectral (IR, NMR) techniques. All the synthesized compounds have been evaluated for their antibacterial and antifungal activity against bacteria Staphylococus aureus and Bacillus subtilis and fungi Fusarium oxisporum and Aspergillus niger when compared with standard drugs.