Synthesis, in vitro and Molecular Docking Studies of l-(3,4-Dimethoxy-phenyl)-5-(4-hydroxy-3-methoxy-phenyI)-penta-l,4-dien-3-one as New Potential Anti-inflammatory

摘要

Synthesis of new asymmetrical curcumin analogue of l-(3,4-dimethoxy-phenyl)-5-(4-hydroxy-3-methoxy-phenyl)-penta-l,4-dien-3-one via condensation reaction between vanillinacetone and veratraldehyde in ethanol has been performed. The in vitro anti-inflammatory activities of the synthesized compounds showed excellent anti-inflammatory activity. In vitro anti-inammatory activity by using inhibition of albumin denaturation technique compared to standard dichlorofenac. Molecular docking studies were performed, where docking of the compound into 6COX active site suggested that it could exert its anti-inflammatory potential by cyclooxygenase inhibition.