4-3-（3，4-二甲氧基苯基）-3-（4-氟苯基）烯酰吗啉合成工艺研究

摘要

对氟吗啉的合成工艺进行了研究，以邻苯二酚为起始原料，通过醚化、付克酰基化、缩合反应制得目标化合物，总收率可达69．1％。目标产物及中间体的结构均经NMR、MS确证。改用低毒和高活性试剂使合成工艺步骤简单，操作安全，条件温和，收率较高，适合大规模制备。%Flumorph was synthesized from catechol via etherification, Friedel--Crafts acyltion reaction and condensation reaction. The overall yield could reach 69. 1%. The product and all intermediates were characterized and verified by NMR and MS. The method has high industrial value thanks to its low production cost, convenient steps, simplicity and high yield.