Synthesis, Characterization and Biological Applications of Random Aliphatic Copolythioesters Using 3,3'-Thiodipropionic Acid

摘要

The aliphatic random copolyester polycyclohexylthiodipropionate-co-cyclohexyldecanedioate (PCTCD) containing sulphur atom in the main chain was synthesized by mixing 3,3'-thiodipropionic acid, decanedioic acid and 1,4-cyclohexanediol monomers with titanium tetra isopropoxide catalyst using direct melt polycondensation method. The different physical properties of copolyester such as inherent viscosity, solubility, differential scanning colorimetry and X-ray diffraction technique was investigated. The chemical structure of the copolyester was investigated by FTIR, ~1H NMR and ~(13)C NMR spectroscopy. The synthesized compounds were tested for human pathogenic bacteria using well diffusion method, in vitro cytotoxicity against normal (Vero cell line) and cancer (A_(549) lung cancer cell line) by MTT assay. Also in vitro antioxidant property of copolymer was studied.