Synthesis, Characterization and Electrochemical Studies on the Interaction Mechanism of Ternary La(III) Complex with DNA

摘要

A new Schiff base ligand (KGOV) was synthesized using potassium salt of glycine and o-vanillin. A ternary complex of lanthanum(III) with this ligand and 1,10-phenanthroline, [La(GOV)(phen)(NO3)](NO3)·3H2O was synthesized and characterized by elemental analysis, IR, TG-DTG, ~1H NMR spectra and molar conductance. The fundamental electrochemical characteristics of the La(III) ternary complex have been studied and the interactivity of La(III) complex with DNA was also studied by cyclic voltammetry. The results suggest that the complex combined with DNA in the form of intercalative binding. The binding ratio between the La(III) ternary complex and DNA was calculated to be 1:1 and the binding constant was 1.13 x 10~5 L mol~(-1).