Atherosclerosis-Preventing Activity of Lactic Acid Bacteria-Fermented Milk-Soymilk Supplemented with Momordica charantia

摘要

In this study,the milk-soymilk and milk-soymilk supplemented with Momordica charantia,a common oriental vegetable possessing medicinal activities,were fermented by lactic bacteria.The objective of this study was to investigate the effects of milk-soymilk and fermented milk-soymilk with or without M.charantia on atherosclerosis in hyperlipidemic hamsters.Fermented 25% milk and 75% soymilk combinations,supplemented with 1% M.charantia solution,can improve the acceptability of the fermented beverage.A total of 72 male Golden Syrian hamsters were divided into 9 groups(n = 8/group),and experimental diets were provided with a normal diet for the normal group and a high-cholesterol diet for others.The milk-soymilk and fermented milk-soymilk with or without M.charantia were administrated for 8 weeks.The milk-soymilk and fermented milk-soymilk with and without M.charantia were able to significantly decrease(p < 0.05)the serum cholesterol and the atherosclerotic plaque in aorta based on the comparison to the high-cholesterol diet(H)group.The groups on fermented milk-soymilk by Lactobacillus plantarum NTU 102 with or without M.charantia could significantly decrease(p < 0.05)the ratio of low-density lipoprotein cholesterol(LDL-C)to high-density lipoprotein cholesterol(HDL-C).The femented milk-soymilk by Lactobacillus paracasei subsp.paracasei NTU 101 supplemented with M.charantia had an anti-atheroscierotic activity by increasing superoxide dismutase(SOD)and total antioxidant status(TAS)activity of the blood and relieving the degree of thiobarbituric acid reactive substances(TBARS)compared to the other treatments.It is concluded that the milk-soymilk and the fermented milk-soymilk supplemented with or without M.charantia by L.paracasei subsp.paracasei NTU 101 are effective in preventing and retarding the hyperlipidemia-induced oxidative stress and atherosclerosis.