Effect of Losmapimod on Cardiovascular Outcomes in Patients Hospitalized With Acute Myocardial Infarction A Randomized Clinical Trial

ODonoghue Michelle L.; Glaser Ruchira; Cavender Matthew A.; Aylward Philip E.; Bonaca Marc P.; Budaj Andrzej; Davies Richard Y.; Dellborg Mikael; Fox Keith A. A.; Gutierrez Jorge Antonio T.; Hamm Christian; Kiss Robert G.; Kovar Frantisek; Kuder Julia F.; Im Kyung Ah; Lepore John J.; Lopez-Sendon Jose L.; Ophuis Ton Oude; Parkhomenko Alexandr; Shannon Jennifer B.; Spinar Jindrich; Tanguay Jean-Francois; Ruda Mikhail; Steg P. Gabriel; Theroux Pierre; Wiviott Stephen D.; Laws Ian; Sabatine Marc S.; Morrow David A.

首页> 外文期刊>JAMA: the Journal of the American Medical Association >Effect of Losmapimod on Cardiovascular Outcomes in Patients Hospitalized With Acute Myocardial Infarction A Randomized Clinical Trial

【24h】

Effect of Losmapimod on Cardiovascular Outcomes in Patients Hospitalized With Acute Myocardial Infarction A Randomized Clinical Trial

机译：Losmapimod对住院急性心肌梗死患者心血管结局的影响随机临床试验

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

IMPORTANCE p38 Mitogen-activated protein kinase (MAPK)-stimulated inflammation is implicated in atherogenesis, plaque destabilization, and maladaptive processes inmyocardial infarction (MI). Pilot data in a phase 2 trial in non-ST elevation MI indicated that the p38 MAPK inhibitor losmapimod attenuates inflammation and may improve outcomes.

机译：重要事项p38丝裂原活化蛋白激酶（MAPK）刺激的炎症与心肌梗死（MI）的动脉粥样硬化，斑块失稳和适应不良过程有关。非ST抬高MI的2期试验的初步数据表明，p38 MAPK抑制剂losmapimod可减轻炎症并可能改善预后。

著录项

来源
《JAMA: the Journal of the American Medical Association》 |2016年第15期|共9页
作者
ODonoghue Michelle L.; Glaser Ruchira; Cavender Matthew A.; Aylward Philip E.; Bonaca Marc P.; Budaj Andrzej; Davies Richard Y.; Dellborg Mikael; Fox Keith A. A.; Gutierrez Jorge Antonio T.; Hamm Christian; Kiss Robert G.; Kovar Frantisek; Kuder Julia F.; Im Kyung Ah; Lepore John J.; Lopez-Sendon Jose L.; Ophuis Ton Oude; Parkhomenko Alexandr; Shannon Jennifer B.; Spinar Jindrich; Tanguay Jean-Francois; Ruda Mikhail; Steg P. Gabriel; Theroux Pierre; Wiviott Stephen D.; Laws Ian; Sabatine Marc S.; Morrow David A.;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类
关键词
入库时间 2022-08-19 15:39:16

相似文献

外文文献
中文文献
专利

1. Effect of Losmapimod on Cardiovascular Outcomes in Patients Hospitalized With Acute Myocardial Infarction A Randomized Clinical Trial [J] . ODonoghue Michelle L., Glaser Ruchira, Cavender Matthew A., JAMA: the Journal of the American Medical Association . 2016,第15期

机译：Losmapimod对住院急性心肌梗死患者心血管结局的影响随机临床试验
2. Effects of Intracoronary Nicorandil on Myocardial Microcirculation and Clinical Outcomes in Patients with Acute Myocardial Infarction: A Meta-Analysis of Randomized Controlled Trials [J] . Shi Liye, Chen Ling, Qi Guoxian, American journal of cardiovascular drugs: drugs, devices, and other interventions . 2020,第2期

机译：脑内Nicorandil对急性心肌梗死患者心肌微循环和临床结果的影响：随机对照试验的荟萃分析
3. Impact of bleeding on mortality after percutaneous coronary intervention results from a patient-level pooled analysis of the REPLACE-2 (randomized evaluation of PCI linking angiomax to reduced clinical events), ACUITY (acute catheterization and urgent intervention triage strategy), and HORIZONS-AMI (harmonizing outcomes with revascularization and stents in acute myocardial infarction) trials. [J] . Mehran R, Pocock S, Nikolsky E, JACC. Cardiovascular interventions . 2011,第6期

机译：经皮冠状动脉介入治疗后出血对死亡率的影响来自于对REPLACE-2（PCI将血管造影与减少临床事件的关联性的随机评估），ACUITY（急性导管插入和紧急干预分类策略）的患者水平汇总分析和HORIZONS-AMI （在急性心肌梗死中采用血运重建术和支架使结果一致）试验。
4. RELATIONSHIP BETWEEN QUANTITATIVE T-WAVE ALTERNANS ESTIMATES AND PARAMETERS DESCRIBING CLINICAL STATUS OF PATIENT IN ACUTE PHASE OF MYOCARDIAL INFARCTION AND OUTCOME RESULTS [C] . Algimantas Krisciukaitis, Renata Simoliuniene, Andrius Macas, International Conference on Bio-inspired Systems and Signal Processing . 2012

机译：定量T波段之间的关系描述心肌梗死急性期患者临床状态的估计和参数
5. The development, implementation and evaluation of a disease management program for post -myocardial infarction patients: A randomized controlled trial. [D] . Young, Wendy I. 2002

机译：心肌梗死后患者疾病管理计划的制定，实施和评估：一项随机对照试验。
6. The impact of oral nicorandil pre-treatment on ST resolution and clinical outcome of patients with acute ST-segment elevation myocardial infarction undergoing primary coronary angioplasty: A randomized placebo controlled trial [O] . Behnaz Akbari, Samad Ghaffari, Naser Aslanabadi, 2020

机译：口服尼可地尔预处理对接受原发性冠状动脉成形术的急性ST段抬高型心肌梗死患者的ST拆分和临床结局的影响：一项随机安慰剂对照试验
7. Impact of Bleeding on Mortality After Percutaneous Coronary Intervention Results From a Patient-Level Pooled Analysis of the REPLACE-2 (Randomized Evaluation of PCI Linking Angiomax to Reduced Clinical Events), ACUITY (Acute Catheterization and Urgent Intervention Triage Strategy), and HORIZONS-AMI (Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction) Trials [O] . Mehran, Roxana, Pocock, Stuart, Nikolsky, Eugenia, 2011

机译：经皮冠状动脉介入治疗后出血对死亡率的影响来自对REPLACE-2（将PCI链接血管造影最大程度减少临床事件的随机评估），急性（急性导管插入和紧急介入分流策略）的患者水平汇总分析的患者水平汇总分析（在急性心肌梗死中通过血运重建和支架使结果一致）试验

Effect of Losmapimod on Cardiovascular Outcomes in Patients Hospitalized With Acute Myocardial Infarction A Randomized Clinical Trial

摘要

著录项

相似文献

相关主题

期刊订阅