ANTICONVULSANT LAMOTRIGINE MAY HAVE ANTIBIOTIC PROMISE

摘要

Antibiotics often target the way bacteria manufacture proteins by inhibiting the function of the ribosomes. In a study published in eLIFE (online, 18 September 2014), researchers aimed to find out whether they could prevent the ribosomes from forming at all. They screened a library of 30,000 compounds, including 3,500 existing drugs, against strains of Esoheria coli and found a number of drug candidates that inhibited growth of the bacteria by inhibition of the ribosome.