Long-term sibutramine linked with heart attacks in at-risk patients

摘要

People at high risk of cardiovascular disease who take sibutramine long-term are more likely to suffer a non-fatal heart attack or stroke, study ? findings show (New England Journal of Medicine 2010;363:905).The Sibutramine Cardiovascular Outcomes Trial (SCOUT) evaluated the long-term effects of sibutramine treatment combined with diet and exercise on the rates of cardiovascular events and cardiovascular death in patients aged 55 years or older with pre-existing cardiovascular disease, type 2 diabetes or both. After a six-week lead-in period, 9,804 overweight or obese participants were randomised to 10-15mg of sibutramine (4,906 subjects) or placebo (4,898 subjects) for a mean time of 3.4 years.